Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 451-530-8 | CAS number: 736150-63-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
TS-ED 532 was tested to investigate the bioaccumulation potential in zebra fish larvae (Danio rerio) using a modified in-vitro procedure based on the OECD Guideline for Testing of Chemicals No. 305 “Bioconcentration: Flow-through Fish Test", which corresponds to the EU Testing Method C.13 Bioconcentration: Flow-through fish test. Based on the mean BCFss results, a conservative estimate of BCF was 981 ± 330, resulting in a log BCF of 2.99 ± 0.14.
Key value for chemical safety assessment
- BCF (aquatic species):
- 981 dimensionless
Additional information
TS-ED 532 was tested to investigate the bioaccumulation potential in zebra fish larvae (Danio rerio) using a modified in-vitro procedure based on the OECD Guideline for Testing of Chemicals No. 305 “Bioconcentration: Flow-through Fish Test", which corresponds to the EU Testing Method C.13 Bioconcentration: Flow-through fish test.
TS-ED 532 is degraded in the environment and metabolised in organisms. Due to its chemical composition, it was not possible to detect actual accumulated concentrations in the organism, why the test was performed with radiolabelled TS-ED 532. Adult stages of zebra fish are generally having a higher metabolising capacity than larval stage and the bioaccumulation study was thus performed with larval stages of zebra fish with a low metabolising capacity, which represents a ‘worst-case’ evaluation of the bioaccumulation potential of TS-ED 532.
Besides the control group, two concentrations were tested i.e 35 µg/L and 70 µg/L. Each concentration was tested in two replicates. The actual exposure concentrations as well as the accumulated amount of TS-ED 532 were verified by determination of the radiolabelled TS-ED 532 by liquid scintillation counting (LSC).
The bioconcentration factor (BCF) was determined as the steady-state BCF (BCFss) as well as based on uptake and depuration rate kinetics (BCFk). Based on the mean BCFss results, a conservative estimate of BCF was 981 ± 330, resulting in a log BCF of 2.99 ± 0.14.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
