Registration Dossier

Administrative data

Description of key information

Sufficient data from QSAR models to classify according to acute oral/dermal endpoints.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
see category report attached under "full study report"
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Species:
rat
Route of administration:
other: Oral
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 834 mg/kg bw
Based on:
other: read across
Dose descriptor:
LD50
Effect level:
0.002 other: mol/kg
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The estimated acute oral LD50 is 834 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
834 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
see category report attached under "full study report"
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Species:
other: Rabbit Rat
Dose descriptor:
LD50
Effect level:
1 969.158 other: mg/kg bdwt
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The estimated acute dermal LD50 is <2000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
1 969 mg/kg bw

Additional information

Justification for classification or non-classification

The criteria for classification as dermal and oral acute toxicant category 4 are fullfiled by assessing these endpoint using adequate QSAR tools.