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EC number: 262-979-2 | CAS number: 61788-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 May 1970 to 24 June 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Version / remarks:
- Draize "Appraisal of Safety of Chemicals in Foods, Drugs and Cosmetics," published by the Association of Food and Drug Officials of the United States; and the Code of Federal Regulations, Title 21, Part 191.12.
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- The purpose of the study was to determine the degree and nature of the irritation induced by the agent upon instillation into the eye of the rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- Lanolin, acetate
- EC Number:
- 262-979-2
- EC Name:
- Lanolin, acetate
- Cas Number:
- 61788-48-5
- Molecular formula:
- Variable
- IUPAC Name:
- Lanolin, Acetates
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No information available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- undiluted, the test material was heated to 56 deg C for instillation.
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 24 hours (single treatment and unwashed)
- Observation period (in vivo):
- Examined and the reaction evaluated at 24h, 48h, and 72h.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): unwashed
- Time after start of exposure: N/A
SCORING SYSTEM: Draize Scale for grading ocular lesions
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
Any other information on results incl. tables
Table 1: Results
Animal No. |
Observation |
Time after administration |
||||
24 hours |
48 hours |
72 hours |
96 hours |
7 days |
||
1 |
Cornea - opacity |
0 |
0 |
0 |
0 |
0 |
Cornea - area |
0 |
0 |
0 |
0 |
0 |
|
Cornea - Score |
0 |
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
|
Iris - score |
0 |
|||||
Conjunctivae - redness |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - chemosis |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - discharge |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - Score |
0 |
|||||
2 |
Cornea - opacity |
0 |
0 |
0 |
0 |
0 |
Cornea - area |
0 |
0 |
0 |
0 |
0 |
|
Cornea - Score |
0 |
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
|
Iris - score |
0 |
|||||
Conjunctivae - redness |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - chemosis |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - discharge |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - Score |
0 |
|||||
3 |
Cornea - opacity |
0 |
0 |
0 |
0 |
0 |
Cornea - area |
0 |
0 |
0 |
0 |
0 |
|
Cornea - Score |
0 |
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
|
Iris - score |
0 |
|||||
Conjunctivae - redness |
1 |
0 |
0 |
0 |
0 |
|
Conjunctivae - chemosis |
1 |
0 |
0 |
0 |
0 |
|
Conjunctivae - discharge |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae - Score |
4 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Non-irritating to the rabbit eye.
- Executive summary:
Under the conditions of the study, the undiluted test substance, may be considered non-irritating to the rabbit eye. The elevated temperature to maintain the fluid state, had no apparent detrimental effect upon the eyes.
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