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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05-15 to 2017-05-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
8 177 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
50 g/L
Incubation duration:
24 h
Temp.:
20 °C
pH:
> 6.92 - < 7.2
Details on results:
The concentration measured did not differ for more than 15 % and Temperatures were kept constant within ± 0.5 °C. Thus, all validity criteria were fulfilled.

Water Solubility Results at 20 °C

Shaking Time at 30 °C

Replicate

No.

Determined Concentration in Water Sample [mg/L]

Water Solubility Mean Value [mg/L]

24 h

1

8130

8161

2

8193

48 h

1

8255

8236

2

8216

72 h

1

8060

8134

2

8207

Overall Mean ± Std. Dev. [mg/L]

 

8177 ± 53

Rel. Std. Dev. [%]

0.6

Conclusions:
The water solubility of the test item was determined to be 8177 ± 53 mg/L at 20 °C using the shake flask method.
Executive summary:

The water solubility of the test item was determined using the shake flask method (OECD 105). Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection. The water solubility of the test item was found to be 8177 ± 53 mg/L.

Description of key information

The water solubility of the test item was determined to be 8177 ± 53 mg/L at 20 °C using the shake flask method (OECD 105).

Key value for chemical safety assessment

Water solubility:
8 177 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined using the shake flask method according to OECD 105 (1995). Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection. The water solubility of the test item was found to be 8177 ± 53 mg/L.