4-methylbenzyl alcohol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-05-15 to 2017-05-26

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

8 177 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

50 g/L

Incubation duration:

24 h

Temp.:

20 °C

pH:

> 6.92 - < 7.2

Details on results:

The concentration measured did not differ for more than 15 % and Temperatures were kept constant within ± 0.5 °C. Thus, all validity criteria were fulfilled.

Water Solubility Results at 20 °C

Shaking Time at 30 °C	Replicate No.	Determined Concentration in Water Sample [mg/L]	Water Solubility Mean Value [mg/L]
24 h	1	8130	8161
	2	8193
48 h	1	8255	8236
	2	8216
72 h	1	8060	8134
	2	8207
Overall Mean ± Std. Dev. [mg/L]			8177 ± 53
Rel. Std. Dev. [%]			0.6

Conclusions:

The water solubility of the test item was determined to be 8177 ± 53 mg/L at 20 °C using the shake flask method.

Executive summary:

The water solubility of the test item was determined using the shake flask method (OECD 105). Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection. The water solubility of the test item was found to be 8177 ± 53 mg/L.

Description of key information

The water solubility of the test item was determined to be 8177 ± 53 mg/L at 20 °C using the shake flask method (OECD 105).

Key value for chemical safety assessment

Water solubility:

8 177 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined using the shake flask method according to OECD 105 (1995). Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection. The water solubility of the test item was found to be 8177 ± 53 mg/L.