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Diss Factsheets
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EC number: 221-218-4 | CAS number: 3033-29-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral
Under the conditions of a OECD 401 and EU Method B.1 guideline study, the oral LD50 value for Dioctyltin mercaptopropionate in Sprague-Dawley rats was established to exceed 2000 mg/kg body weight.
Dermal
By read-across to Dioctyltin oxide, the dermal LD50 of Dioctyltin mercaptopropionate, corrected for molecular weight, is considered to be greater than 2488 mg/kg bodyweight.
Dermal: Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
The acute dermal median lethal dose (LD50) of DOTO determined in a OECD 402 and EU Method B.1 guideline study
in the Wistar strain of rat was determined to be greater than 2000 mg/kg bodyweight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 488 mg/kg bw
Additional information
Oral
The acute oral toxicity potential of Dioctyltin mercaptopropionate to the rat was investigated in accordance with the standardised guidelines OECD 401 and EU Method B.1 under GLP conditions using a fixed dose method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A single group of 5 male and 5 female Sprague-Dawley strain rats was dosed at a level of 2000 mg/kg of Dioctyltin mercaptopropionate prepared in coconut oil and observed for a period of 14 days. All animals were killed at the end of the observation period and subjected to necropsy examination.
No mortality occurred during the 14 day post-dose observation period. A slight loss of body weight or a reduced body weight gain were observed in the females at the end of the first week of the study. Clinical signs observed included piloerection, a soft faeces production and a swollen abdomen. A hunched posture and hair loss were also noted in the females. In addition, the skin/fur of the ventral region appeared dirty in the majority of the animals. Necropsy examination revealed no abnormalities.
These results indicate that the test material has little toxic effect in the rat following oral administration of a single dose at a level of 2000 mg/kg. The lack of mortality demonstrates the LD50 to be in excess of 2000 mg/kg body weight.
Under the conditions of this study, the oral LD50 value in Sprague-Dawley rats was established to exceed 2000 mg/kg body weight.
Inhalation
In accordance with column 2 of section 8.5.2 of REACH, the acute toxicity by inhalation study with Dioctyltin mercaptopropionate has been omitted as scientifically unjustified on the grounds that inhalation exposure to the substance is unlikely under normal conditions of use. The acute toxicity of the substance has been determined adequately by the oral route.
Dermal: Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
The acute dermal toxicity of the DOTO was investigated in accordance with standardised guidelines OECD 402 and EU Method B.3. During the study, a group of ten animals (five males and five females) was given a single, 24 -hour, semi-occluded dermal application of the test material to intact skin at a dose level of 2000 mg/kg bw. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy. Under the conditions of the study there were no deaths and no signs of systemic toxicity. Animals showed normal weight gains and there were no signs of dermal irritation. Furthermore, no abnormalities were noted at necropsy. The acute dermal median lethal dose (LD50) of the test material in the Wistar strain of rat was therefore determined to be greater than 2000 mg/kg bw.
By read-across to Dioctyltin oxide, the dermal LD50 of Dioctyltin mercaptopropionate, corrected for molecular weight, is considered to be greater than 2488 mg/kg bodyweight.
Justification for classification or non-classification
The oral LD50 of Dioctyltin mercaptopropionate is > 2000 mg/kg bw. By read-across to Dioctyltin oxide, the dermal LD50 of Dioctyltin mercaptopropionate corrected for molecular weight, is considered to be greater than 2488 mg/kg bodyweight.
Target substance and source substances share the identical organotin moiety, and the organotin moiety is generally recognized as the relevant toxophore of organotins. Mercaptopropionic acid, which is as mercaptopropionate the moiety of the target substance which is not covered by the source substance, is not classified for acute toxicity.
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, Dioctyltin mercaptopropionate does not require classification with respect to acute toxicity via the oral or dermal route. Dioctyltin mercaptopropionate is not classified for acute inhalative toxicity because of lacking data
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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