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EC number: 908-700-6 | CAS number: 64519-82-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Feb - 27 Feb 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- effusion method: Knudsen cell
- Remarks:
- vapour pressure calculated by extrapolation of measured values
- Specific details on test material used for the study:
- Store at ambient temperature, dry
- Temp.:
- 20 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 50 °C
- Vapour pressure:
- 0 hPa
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Feb - 08 Mar 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- effusion method: Knudsen cell
- Remarks:
- vapour pressure calculated by extrapolation of measured values
- Specific details on test material used for the study:
- Store at ambient temperature, dry
- Temp.:
- 20 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 hPa
- Temp.:
- 50 °C
- Vapour pressure:
- 0 hPa
Referenceopen allclose all
Thermal Stability
The DSC showed that in the temperature ranges of 70 °C – 110 °C and 110
°C – 150 °C the test item showed two endothermic effects, which can be
assigned to a separation of crystallisation water and the melting of the
test item (see study reference ‘4.12 Auto-flammability and 4.13
Flammability_Self-heating properties of substances and mixtures’).
Starting at a temperature of 240 °C, an exothermic effect was observed,
which was not finished up to the maximum test temperature of 300 °C. Due
to this, this exothermic effect has decomposition energy of greater than
-250 J/g.
Table 1 – DSC measurement results
Sample weight [mg] |
Start [°C] |
Energy [J/g] |
9.48 |
70 (endothermic) |
20 |
Effusion Method: Knudsen cell
The vapour pressure was measured in the temperature range of
120.9 °C to 140.8 °C. The measured vapour pressure values together with
the measured temperatures are listed in Table 2.
Table 2 – Effusion method results
No. |
Temperature [°C] |
Vapour pressure [Pa] |
1 |
120.9 |
4.0 × 10-3 |
2 |
125.9 |
5.0 × 10-3 |
3 |
130.9 |
6.2 × 10-3 |
4 |
135.8 |
7.4 × 10-3 |
5 |
140.8 |
8.7 × 10-3 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine Equation
Log p = A + B/T = A + B/(C+ϑ)
were derived by regression of the data points to
A = 4.5847
B = -2748.06
C = 273.15.
The vapour pressure of the test item Isomalt-ST Typ PF
calculated by extrapolation of the measured vapour pressure curve for
the temperatures 20 °C, 25 °C and 50 °C, according to Regulation EC
No. 440/2008 Method A.4.Vapour Pressure and OECD Test Guideline 104
(2006) is shown in table 3.
Table 3 - Calculated vapour pressure values for 20 °C, 25 °C
and 50 °C
Temperature [°C] |
Vapour pressure [Pa] |
20 |
1.6 × 10 -5 |
25 |
2.3 × 10 -5 |
50 |
1.2 × 10 -4 |
Thermal Stability
The DSC showed that in the temperature ranges of 80 °C – 110 °C and 110
°C – 160 °C the test item showed two endothermic effects, which can be
assigned to a separation of crystallisation water and the melting of the
test item (see study reference ‘4.12 Auto-flammability and 4.13
Flammability_Self-heating properties of substances and mixtures’).
Starting at a temperature of 240 °C, an exothermic effect was observed,
which was not finished up to the maximum test temperature of 300 °C. Due
to this, this exothermic effect has decomposition energy of greater than
-250 J/g.
Table 1 – DSC measurement results
Sample weight [mg] |
Start [°C] |
Energy [J/g] |
9.02 |
80 (endothermic) |
30 |
Effusion Method: Knudsen cell
The vapour pressure was measured in the temperature range of
110.9 °C to 130.8 °C. The measured vapour pressure values together with
the measured temperatures are listed in Table 2.
Table 2 – Effusion method results
No. |
Temperature [°C] |
Vapour pressure [Pa] |
1 |
110.9 |
1.0 × 10-3 |
2 |
115.9 |
1.9 × 10-3 |
3 |
120.9 |
3.3 × 10-3 |
4 |
125.9 |
5.6 × 10-3 |
5 |
130.9 |
7.7 × 10-3 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine Equation
Log p = A + B/T = A + B/(C+ϑ)
were derived by regression of the data points to
A = 14.9635
B = -6882.85
C = 273.15
The vapour pressure of the test itemIsomalt-GS Typ PF
calculated by extrapolation of the measured vapour pressure curve for
the temperatures 20 °C, 25 °C and 50 °C, according to Regulation EC
No. 440/2008 Method A.4.Vapour Pressure and OECD Test Guideline 104
(2006) is shown in table 3.
Table 3 - Calculated vapour pressure values for 20 °C, 25 °C
and 50 °C
Temperature [°C] |
Vapour pressure [Pa] |
20 |
3.1 × 10-9 |
25 |
7.6 × 10-9 |
50 |
4.6 × 10-7 |
Description of key information
3.1E-11 hPa to 1.6E-07 hPa at 20 °C (Extrapolation of measured vapour pressure using Effusion method, OECD 104)
The result is given as a range based on the results obtained from two types of Isomalt (ST and GS).
Key value for chemical safety assessment
Additional information
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