Registration Dossier
Registration Dossier
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EC number: 254-991-1 | CAS number: 40594-65-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
non mutagenic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The mutagenic potential of the substance was evaluated according to the OECD Guideline 471 and according to the method found in Ames, B.N et al. (1975), Gatehouse, D. (1994), Maron, D.M. and Ames, B.N. (1983). The substance was tested in 5 different concentrations ranging from 0.06 to 5 μg/plate in the plate incorporation test with and without metabolic activation (S9 mix). Two plates per dose per strain were incubated for 48 hours at 37 °C, after which the revertant colonies were evaluated for the test plates, negative and positive controls. Cytotoxicity was observed at the highest concentrations of TA 1537, TA100 and TA98 without metabolic activation and at the highest concentration at TA1537, TA1535 and TA98 with metabolic activation.
The substance did not show any evidence of mutagenicity under the test conditions.
Justification for classification or non-classification
The substance did not show any evidence of mutagenicity in the in vitro gene mutation study in bacteria cells. It is, therefore, not classified for mutagenicity according to the CLP Regulation (EC) No. 1272/2008.
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