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Diss Factsheets
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EC number: 907-713-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.06.2000 to 14.07.2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Inhibition control in ready biodegradability test performed according to OECD 301F
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Purity: 97.0% (carbonyl content)
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- Fresh activated sludge from a biological waste water treatment plant treating predominantly domestic sewage (City of Geneva) was used.
The sludge is collected in the morning, washed three times in the mineral medium (by centrifuging at 1000 g for 10 minutes, discarding the supernatant and resuspending in mineral medium) and kept aerobic until being used on the same day. - Water media type:
- other: deionised water containing less than 10 mg/l dissolved organic carbon.
- Total exposure duration:
- 28 d
- Test temperature:
- 22°C
- pH:
- 7.36 - 8.06
- Nominal and measured concentrations:
- 100 mg/l for test and reference substances
- Details on test conditions:
- Activated sludge: dry weight of suspended solids = 2.232 g/l
To obtain a concentration of 30mg/l (dry weight) in a 250 ml flask, 3.36 ml of sludge is needed (inoculum). - Reference substance (positive control):
- yes
- Remarks:
- Sodium benzoate (purity: min 99%)
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Comparison of respiration of flasks containing test chemical + positive control and flasks containing positive control only
- Details on results:
- The curves obtained with the reference substance alone and with Isoraldeine 70 + reference substance show no significant toxic effect of Isoraldeine 70 on the microorganisms at the test concentration (see illustration section).
- Results with reference substance (positive control):
- Degradation of sodium benzoate exceeds 40% after 7 days and 65% after 14 days: the activity of the inoculum is thus verified (validity criterion).
- Validity criteria fulfilled:
- yes
- Remarks:
- Degradation of sodium benzoate exceeds 40% after 7 days and 65% after 14 days: the activity of the inoculum is thus verified (validity criterion).
- Conclusions:
- The toxicity of Isoraldeine 70 to microorganisms was assessed in an inhibition control of a standardised ready test performed according to OECD 301F. Isoraldeine 70 did not inhibit the degradation of the positive control, sodium benzoate, at a test concentration of 100mg/L. This concentration can be considered the NOEC for the toxicity to STP microorganisms.
ISORALDEINE 70 was a source substance used to address the biodegradation endpoint in a read-across approach. This source substance and the registered substance (target) are both members of the methyl ionone family. There are differences in their isomeric composition. The main constituents of the target substance are n-methyl-alpha-ionone (30-77%) and n-methyl-beta-ionone (10-50%) while ISORALDEINE 70 is composed of predominantly n-methy-alpha-ionone (20-30%) and iso-methyl-alpha-ionone (60-70%). Any minor components in both substances are other methyl ionone isomers.
As demonstrated in the read-across justifications for the daphnia and algae endpoints, where three source substance of varying isomeric composition were used, this family of isomeric substances exhibit similar aquatic toxicity irrespective of the isomer ratios present. Thus it is considered that the NOEC derived from the biodegradation study of ISORALDEINE 70, gives a reliable estimate of the toxicity to microorgansims of the registered substance, “Reaction mass of 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one and 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one”.
Reference
Description of key information
No standard microbial inhibition test data is available for the registered substance. Therefore data derived from available ready biodegradation tests is being used to derive PNECSTP. An inhibition control was included in the biodegradation study of ISORALDEINE 70 (Rudio, 2000) which showed no toxicity at a test concentration of 100mg/L. This concentration can be considered as a NOEC for the toxicity to STP microorganisms.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
ISORALDEINE 70 was a source substance used to address the biodegradation endpoint in a read-across approach. This source substance and the registered substance (target) are both members of the methyl ionone family. There are differences in their isomeric composition. The main constituents of the target substance are n-methyl-alpha-ionone (30-77%) and n-methyl-beta-ionone (10-50%) while ISORALDEINE 70 is composed of predominantly n-methy-alpha-ionone (20-30%) and iso-methyl-alpha-ionone (60-70%). Any minor components in both substances are other methyl ionone isomers.
As demonstrated in the read-across justifications for the daphnia and algae endpoints, where three source substance of varying isomeric composition were used, this family of isomeric substances exhibit similar aquatic toxicity irrespective of the isomer ratios present. Thus it is considered that the NOEC derived from the biodegradation study of ISORALDEINE 70, gives a reliable estimate of the toxicity to microorgansims of the registered substance, “Reaction mass of 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one and 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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