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EC number: 214-780-7 | CAS number: 1193-81-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Reliability has been presented as 2 because a protocol somewhat similar to OECD Guideline has been followed but pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 1-cyclohexylethanol
- EC Number:
- 214-780-7
- EC Name:
- 1-cyclohexylethanol
- Cas Number:
- 1193-81-3
- Molecular formula:
- C8H16O
- IUPAC Name:
- 1-cyclohexylethanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 210-225 g; females: 210-245 g
- Fasting period before study: not indicated
IN-LIFE DATES: not specified, all animals were sacrificed at the end of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE APPLIED: 2510 mg/kg bw
- Doses:
- 1260, 1580, 2000 and 2510 mg/kg bodyweight
- No. of animals per sex per dose:
- 1260 mg/kg bw: 3 males, 2 females
1580 mg/kg bw: 2 males, 3 females
2000 mg/kg bw: 3 males, 2 females
2510 mg/kg bw: 2 males, 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not indicated
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 950 - <= 2 260
- Mortality:
- At the lowest dose, no animal died while at the highest dose all animals (2 males and 3 females) died. At 1580 mg/kg bw, out of the two males and the three females tested, one male died. At 2000 mg/kg bw, from the three males and the two females tested, two males died. Mortality occured in one to six days, mostly within one day.
- Clinical signs:
- other: Reduced appetite and activity (one to three days in survivors), increasing weakness, ocular discharge and collapsing occured.
- Gross pathology:
- The animals who died during the study showed lung hyperemia, discoloration in areas of the liver and gastrointestinal inflammation. The animals who survived during the study showed normal viscera.
- Other findings:
- Male animals seemed to be more sensitive since 1 out of 2 and 2 out of 3 male animals tested, died at dose levels of 1580 and 2000 mg/kg bw, respectively, while no female animals died at these doses. Due to limited animal numbers it is justified to add the results of males and females per dose, resulting in an LD50 of 2100 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified, criteria not met
- Remarks:
- according to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- In the acute oral toxicity test the substance showed an LD50 of 2100 mg/kg bw for male and female animals combined.
- Executive summary:
An acute oral toxicity study was performed somewhat similar to OECD TG 401. Five rats per group (2 or 3 males and 2 or 3 females) were exposed to the substance in dose levels of 1260, 1580, 2000 and 2510 mg/kg bodyweight and observed for 14 days. At the lowest concentration no animal died, while at the highest concentration all animals died. Male animals seemed to be more sensitive since 1 out of 2 and 2 out of 3 male animals tested, died at dose levels of 1580 and 2000 mg/kg bw, respectively, while no female animals died at these doses. Mortality was observed in one to six days, mostly within one day. Clinical signs included reduced apetite and activity (one to three days in survivors), increasing weakness, ocular discharge and collapsing. At the end of the study, necropsy was performed on the surviving animals which showed normal viscera. Necropsy on animals that died during the study showed lung hyperemia, discoloration in areas of the liver and gastrointestinal inflammation. Due to the limited animal numbers it is justified to add results of males and females per dose, resulting in an LD50 of 2100 mg/kg bw.
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