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Diss Factsheets
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EC number: 213-995-3 | CAS number: 1071-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Lack of selective developmental toxicity of three butanol isomers administered by inhalation to rats
- Author:
- Nelson BK, Brightwell WS, Khan A, Burg JR, Goad PT
- Year:
- 1 989
- Bibliographic source:
- Fund Appl. Toxicol 12:469-479
- Reference Type:
- publication
- Title:
- Behavorial teratology investigation of 1-butanol in rats
- Author:
- Nelson BK, Brightwell WS, Robertson SK, Khan A, Krieg EF, Massarz VJ
- Year:
- 1 989
- Bibliographic source:
- Neurotoxicol Teratol 11:313-315
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Male SD rats (18/group) were exposed to concentration of 0, 3000, 6000 ppm 1-butanol for 6 weeks. The males were then mated to non-exposed females.
Separate groups of 15 pregnant females were exposed to the same concentrations from day 1 to 20 of gestation, and were allowed to deliver. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- male: 6 weeks before mating
female: day 1 - 20 of gestation - Frequency of treatment:
- 7 h/day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm
- Dose / conc.:
- 3 000 ppm
- Dose / conc.:
- 6 000 ppm
- No. of animals per sex per dose:
- female 15; male 18
- Control animals:
- yes
Results and discussion
Results: P0 (first parental generation)
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
Effect levels (P0)
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 6 000 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: pregnancy rate
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEC
- Generation:
- F1
- Effect level:
- ca. 6 000 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- developmental neurotoxicity
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
- Lowest effective dose / conc.:
- 6 000 ppm
- Treatment related:
- no
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for maternal and paternal animals, and their offspring was 6000 ppm (18189 mg/m3)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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