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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
to 2000-6-8
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
no

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
113 mg/kg bw
95% CL:
64 - 199
Clinical signs:
other: The test substance caused effects on the autonomous and central nervous system as well as a gastro intestinal irritation together with cardiovascular changes.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
In an acute oral toxicity study similar to OECD 401 the LD50 was determined to be 113 mg/kg bw in female rats.
Executive summary:

The test substance caused effects on the autonomous and central nervous system as well as a gastro intestinal irritation together with cardiovascular changes. These changes together may have been the cause of death. The following LD50 was calculated for females: 113 mg/kg body weight. The limits of confidence were 64 and 199 mg per kg body weight. The slope was 2.98.