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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- other: EDI-Richtlinien für die Untersuchung von Abwasser, 1974
- Deviations:
- yes
- Remarks:
- Carried out on the computerized BAROMAT apparatus. Test substance was not water soluble; stable suspensions were prepared.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184; Trade name D 16 - 51
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room-temperature (20 - 23 deg C) - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: waste water
- Details on inoculum:
- Polyvalent waste-water bacteria collected on June 18, 1981, in the aeration unit of the sewage treatment plant of Rheinfelden, Switzerland.
- Duration of test (contact time):
- 5 d
- Initial conc.:
- 5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Initial conc.:
- 40 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Temperature: 20 +/- 1 deg C
Lighting: darkness (water-bath) - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- other: BOD5
- Remarks on result:
- other: see results below
- Parameter:
- BOD5
- Value:
- 7.6 other: mg O2/L
- Remarks on result:
- other: 5 mg/L TK 12 184 consumed 7.6 mg oxygen/L = 88.4 % of the Theoretical Oxygen Demand (BODT).
- Remarks:
- At concentrations of 10, 20 and 40 mg/L TK 12 194, the oxygen demand was below the range of an accurate measurement.
- Parameter:
- ThOD
- Value:
- 8.6 other: 8.6 mg O2/L
- Remarks on result:
- other: calculated
- Remarks:
- according to OECD Method No. 301D, 1980
- Results with reference substance:
- 20 mg/L Sodium benzoate used as a reference substance in this test consumed 24.4 mg O2/L equal to 76.3 % of the
theoretical oxygen demand. - Conclusions:
- Under these test conditions, 5 mg/L TK 12 184 consumed 7.6 mg oxygen/L = 88.4 % of the Theoretical Oxygen Demand (BODT). At concentrations of 10, 20 and 40 mg/L TK 12 184, the oxygen demand was below the range of an accurate measurement.
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Deutsche Einheitsverfahren zur Wasser-, Abwasser- und Schlammuntersuchung, Verlag Chemie Weinheim (1979). Method H 41 - 1, pages 1-6, DIN 38 409, 9. Lieferung, Ausgabe 1981
- Deviations:
- not specified
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184; trade name D 16 - 51
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 20 - 24 deg C - Inoculum or test system:
- other: Potassiumbichromate as oxidizing agent
- Duration of test (contact time):
- 110 min
- Initial conc.:
- 170 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- other: COD
- Details on study design:
- Vessels: 250 ml COD - flasks with reflux condenser
Oxidizing agent: 10 ml K2Cr207
pH: <1
Tempertaure 148 + 30 deg C / Reflux - Parameter:
- other: COD
- Remarks on result:
- other: see results below
- Parameter:
- COD
- Value:
- 1 559.4 mg O2/g test mat.
- Remarks on result:
- other: S.D. = 0.15%
- Conclusions:
- Under these standard test conditions, the Chemical Oxygen Demand (COD) for TK 12 184 was 1559.40 mg Oxygen / g TK 12 184 (Standard Deviation 0.15 %)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- Volume of test solution was 1.5 liters instead of 3.0 liters.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12184; trade name D 16-051
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. 312-187
- Expiration date of the lot/batch: 12/1985
- Purity: commercial grade
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Bacteria collected fron activated sludge of the sewage treatment plant of CH-4153 Reinach on O2/01/85
- Details on inoculum:
- Preparation was carried out according to the method described in the guideline.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- Vessels: 2 liters flasks equipped with gas inlet and magnetic stirrer.
Water: The test medium was prepared according to the method described in the guideline.
Temperature: 22 + or - 2 degrees
Air: Approx. 50 mL/min free of carbon dioxide. - Reference substance:
- aniline
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 11
- Sampling time:
- 28 d
- Remarks on result:
- other: at 10 mg/L concentration
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 12
- Sampling time:
- 28 d
- Remarks on result:
- other: at 20 mg/L concentration
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under these guideline test condition (OECD 301B), TK 12 184 was not readily biodegradable. At concentrations of 10 or 20 mg/L, 11 and 12 percent degradation, respectively, was achieved within 28 days.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- Predicted by US EPA model BIOWIN v4.10
- GLP compliance:
- no
- Details on results:
- Biowin1 (Linear Model Prediction) : Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Hours
Biowin5 (MITI Linear Model Prediction) : Readily Degradable
Biowin6 (MITI Non-Linear Model Prediction): Not Readily Degradable
Biowin7 (Anaerobic Model Prediction): Does Not Biodegrade Fast
Ready Biodegradability Prediction: YES - Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The US EPA BIOWIN v4.10 model predicts TGEPO (CAS No. 83547-95-9) to be readily biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): domestic wastewater treatment plant (sewage works, Darmstadt, Germany).
- Preparation of inoculum for exposure: centrifugation, resuspension of solid mterial in tap water (repeat three (3) time).
- Pretreatment: Aliqout of wet sludge material was weighed, dried, and the ratio of wet sludge material to dry weight was determined.
- Concentration of sludge: Aliqouts corresponding to 1.5 g dry sludge material were mixed with one (1) liter of test water (equals 1.5 g/L). - Duration of test (contact time):
- 28 d
- Initial conc.:
- 102 g/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- Calculated from the decrease of pressure in the reaction vessel.
- Details on study design:
- Principle: The test flasks prepared according paragraph 6.6 were incubated at 22 ± 2 °C. The pressure decrease in the reaction vessels was measured over complete experimental phase of 28 days using the BSB Sensomat system, Aqualytic Dortmund. The test flasks were closed gastight by a measuring head. Potassium hydroxide solution (45%) was used for trapping the produced carbon dioxide. The amount of O2 consumed by the activated sludge was calculated from the decrease of pressure in the reaction vessel.
Identification: Each test unit was uniquely identified with the study number, treatment and replicate number. - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- Inoculum Control: The oxygen demand of the inoculum control (medium and inoculum) was 20 mg O2/L and thus not greater than 60 mg O2/L within 28 days as required by the test guideline.
pH-Value:The pH-value of the test item flasks at the end of the test was within the range of pH 6.0 to 8.5 as required by the test guideline.
Reference Item: The percentage degradation of the reference item should reach the level for ready biodegradability (>60%) within 14 days as required by the test guideline.
The reference item sodium benzoate was degraded to more than 60% after 4 days of incubation.
Test Item: The difference of duplicate values for the degradation of the test item at the plateau, at the end of the test and at the end of the 10-day window should be less than 20%. The validity criterion was fulfilled. - Parameter:
- % degradation (O2 consumption)
- Value:
- 22
- Sampling time:
- 3 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 66
- Sampling time:
- 10 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 82
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The degradation rate of 2-Ethylhexyl Thioglycolate reached 60% within the 10-day window and after 28 days of incubation. According to the test guideline, 2-Ethylhexyl Thioglycolate is considered to be readily biodegradable.
Referenceopen allclose all
The biodegradation of the reference substance aniline (20 mg/L) was calculated as 100 % in 28 days
Description of key information
Under guideline test condition (OECD 301B), TK 12 184 was not readily biodegradable at concentrations of 10 or 20 mg/L, achieving 11 and 12 percent degradation, respectively, within 28 days. In a BOD5 study, 5 mg/L TK 12 184 consumed 7.6 mg oxygen/L = 88.4 % of the Theoretical Oxygen Demand (BODT). At concentrations of 10, 20 and 40 mg/L TK 12 184, the oxygen demand was below the range of an accurate measurement. These results indicate that TK 12 184 is readily biodegradable at concentrations below those employed in the OECD 301B test.
Under standard test conditions, the Chemical Oxygen Demand (COD) for TK 12 184 was determined to be 1559.40 mg Oxygen / g TK 12 184 (Standard Deviation 0.15 %).
The US EPA BIOWIN v4.10 model predicts this substance to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
- Type of water:
- freshwater
Additional information
TGEPO was not shown to be readily biodegradable at concentrations of 10 or 20 mg/L. BOD5 results demonstrate ready biodegradability at a concentration of 5 mg/L, and indicate possible inhibition of the inoculum at higher test concentrations. Under standard test conditions, the Chemical Oxygen Demand (COD) for TK 12 184 was determined to be 1559.40 mg Oxygen / g TK 12 184 (Standard Deviation 0.15 %). While these results do not fully meet the ready biodegradability criteria, the weight of available evidence indicates that TK 12 184 is at least inherently biodegradable and not persistent. This is further supported by the US EPA BIOWIN v4.10 model, which predicts this substance to be readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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