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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 03 January 2018 to 31 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
EC Number:
615-206-1
Cas Number:
709031-45-8
Molecular formula:
C6H10N2O.CH4O3S
IUPAC Name:
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
Test material form:
solid
Details on test material:
- Appearance: Light tan solid
- Storage conditions: At room temperature protected from light

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
194.5 °C
Decomposition:
yes
Decomp. temp.:
195 °C
Remarks on result:
other: Decomposition started during melting.

Any other information on results incl. tables

DSC EXPERIMENT 1

Endothermic peak between 175°C and 200°C (extrapolated onset temperature: 194.505°C) directly followed by an exothermic effect starting at 200°C. The endothermic effect was most likely obtained due to melting of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a dark brown molten residue remained in the sample container (original colour: light tan). 

DSC EXPERIMENT 2

In order to investigate the melting peak, Experiment 2 was stopped directly after the endothermic peak.  Extrapolated onset temperature: 194.545°C. After the experiment, a light yellow molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item. 

 

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

Applicant's summary and conclusion

Conclusions:
The melting temperature of the substance was determined to be 194.5°C.
Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 194.5°C. Reaction and/or decomposition of the substance started during melting.