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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation / corrosion, in vivo (OECD 404): not irritating

Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)

Eye irritation / serious eye damage, in vivo (OECD 405): not irritating

Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Refer to the analogue approach justification provided in IUCLID section 13
Reason / purpose for cross-reference:
read-across source
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0.66
Max. score:
4
Reversibility:
fully reversible within: 72 h
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982a
Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
Conclusions:
Slight erythema and edema formation were observed after 4 h exposure of the source substance to shaved rabbit skin under occlusive conditions. Effects were fully reversible within 7 days.
Executive summary:

The skin irritation / corrosion potential of the target substance is predicted based on an adequate and reliable in vivo study of a structural analogue source substance. Exposure for 4 h of the test substance to the shaved skin of rabbits under occlusive conditions resulted in slight erythema and edema formation. Effects were fully reversible within 7 days. Therefore, no hazard regarding skin irritation / corrosion is identified for the target substance. As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the skin irritation / corrosion potential.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Refer to the analogue approach justification provided in IUCLID section 13
Reason / purpose for cross-reference:
read-across source
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
all 3 animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: reversibility not applicable
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982b
Irritation parameter:
iris score
Basis:
mean
Remarks:
all 3 animals
Time point:
24/48/72 h
Score:
0
Max. score:
2
Reversibility:
other: reversibility not applicable
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982b
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
all 3 animals
Time point:
24/48/72 h
Score:
0
Max. score:
3
Reversibility:
other: reversibility not applicable
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982b
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
all 3 animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: reversibility not applicable
Remarks on result:
other: Source: CAS No. 38640-62-9, Meisel, 1982b
Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
Conclusions:
Application of the unchanged source substance to the eyes of rabbits resulted in no effects regarding corneal opacity, iridial, conjunctival and chemosis responses. The mean scores of all effects at 24/48/72 h over all 3 animals was 0.
Executive summary:

The eye irritation potential of the target substance is predicted based on an adequate and reliable in vivo study of a structural analogue source substance. Application of the unchanged test substance to the eyes of rabbits resulted in no occular effects at all. The mean scores of all effects at 24/48/72 h for each animal was 0. Therefore, for the target substance no hazard regarding eye irritation / severe eye damage is identified. As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the eye irritation potential.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No data on skin irritation / corrosion and eye irritation / serious eye damage with 2,6-diisopropylnaphthalene (CAS 24157-81-1) are available. These endpoints, therefore, are assessed by means of read-across from the analogue source substance bis(isopropyl)naphthalene (CAS 38640-62-9).

Skin irritation / corrosion

The potential to induce skin irritation or corrosion of bis(isopropyl)naphthalene (CAS No. 38640-62-9) was tested in an in vivo study according to OECD guideline 404 under GLP conditions (Meisel, 1982a). The application of 0.5 mL of the unchanged test substance to the shaved skin of the dorsal area of the trunk (size approx. 2.5 x 2.5 cm) of 3 female New Zealand White rabbits for 4 h under an occlusive and impermeable adhesive dressing resulted in slight skin reactions. Skin reactions were scored after 1, 24, 48, 72 h, 7 days and 14 days after removal of the test patch. The remaining test substance was removed by wiping with single-use paper towels. Slight erythema formation (24/48/72 h mean score 1 in all 3 animals) and slight edema (24/48/72 h mean score 0.33 for 2 and 0.66 for the remaining animal) were observed. In one animal, a slight lesion (48 h) and scab formation (72 h) was observed at the application site in addition. All animals showed desquamation on Day 7. After 14 days, all irritation effects had subsided, and no more findings were noted. The test substance was assessed to have no irritation / corrosion potential.

Eye irritation / serious eye damage

In an in vivo eye irritation study according to OECD guideline 405 following GLP provision with bis(isopropyl)naphthalene (CAS No. 38640-62-9) (Meisel, 1982b), 0.1 mL of the unchanged test substance was instilled in the conjunctival sac of one eye of 3 New Zealand White rabbits. The untreated eye of each animal served as control. Occular reactions were scored according to the Draize scheme. Only a slightly irritating effect (conjunctivae redness score 1) was observed in all test animals 1 h after test substance administration. At the 24 h reading, this finding had subsided and was not seen any more. Scores for all eye irritation parameters in all animals were 0, starting from 24 h onwards. The observation was terminated at the 72 h reading time point due to the lack of any visible effects. The test substance was evaluated not to induce eye irritation.

Conclusion

Based on the results of the in vivo studies for skin irritation / corrosion and eye irritation / serious eye damage with the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) no potential to induce skin or eye irritation is expected for the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1).

Justification for classification or non-classification

The available data on skin irritation / corrosion and eye irritation / serious eye damage for the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP). Data are, therefore, conclusive but not sufficient for classification. Based on an analogue read-across approach, the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1) also does not warrant classification for these human health endpoints.