Registration Dossier
Registration Dossier
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EC number: 202-495-0 | CAS number: 96-27-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CCFR 1500.40
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- study was conducted prior to the GLP legislation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-mercaptopropane-1,2-diol
- EC Number:
- 202-495-0
- EC Name:
- 3-mercaptopropane-1,2-diol
- Cas Number:
- 96-27-5
- Molecular formula:
- C3H8O2S
- IUPAC Name:
- 3-sulfanylpropane-1,2-diol
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- Batch 297-1382
Test animals
- Species:
- rabbit
- Strain:
- other: Albino, not further specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not reported
- Doses:
- 0.2, 0.50, 0.75, 1.00, 2.00 mL/kg bw
249, 623, 935, 1247, 2494 mg/kg bw (using density of 1.25 g/mL) - No. of animals per sex per dose:
- 5
- Control animals:
- not required
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 0.54 mL/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 673 mg/kg bw
- Based on:
- test mat.
- Mortality:
- mg/kg bw Dead total Mortality
249 0 5 0%
623 2 5 40%
935 4 5 80%
1247 5 5 100%
2494 5 5 100% - Clinical signs:
- other: not reported
- Gross pathology:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on an LD50 of 673 mg/kg bw, monothioglycerol should be classified as Acute Tox 3 - H311: Toxic in contact with skin.
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