Antimony pentachloride

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

other: human case report

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Reasonably well-documented case report.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other: case report

Title:

The work of an occupational hygiene service in environmental control

Author:

McCallum R.I.

Year:

1963

Bibliographic source:

Ann Occup Hyg. Vol. 6, pp. 58-64. Pergamon Press Ltd., 1963

Materials and methods

Study type:

health record from industry

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Men working at a plant near Newcastle in United Kingdom with the production of antimony oxide and the pure metal from sulphide ore by various smelting processes were radiographed. The examination was performed by the occupational hygiene service .

GLP compliance:

no

Remarks:

not applicable

Test material

Test material information

Constituent 1

Reference substance name:

Diantimony trioxide

EC Number:

215-175-0

EC Name:

Diantimony trioxide

Cas Number:

1309-64-4

Molecular formula:

Sb2O3

IUPAC Name:

dioxodistiboxane

Test material form:

not specified

Method

Type of population:

occupational

Ethical approval:

not specified

Details on study design:

- examination of workers and retired workers especially x-ray of the lungs

Results and discussion

Results:

The rash consisted of papules and pustules around sweat and sebacous glands. It affected particularly the fore arms and thighs and the flexures and did not appear on the face, hands or feet. The spots disappeared rapidly over a weekend or public holiday, but reappeared on return to work.
Over hundred men were employed but the frequency of dermatitis was not stated.

Any other information on results incl. tables

Further results:

- a number of men working on this antimony plant at present have symptomless lung changes on radiographic examination

(first noticed in another investigation)

- Observation did not show any alteration in the radiological opacities, but:

2 men developed tuberculosis lesions (which responded promptly to chemotherpy)

- one man with pneumoconiosis who had respiratory symptoms had chronic bronchitis with respiratory obstruction

- men exposed to antimony excrete it in their urine

- examination of urine sample of 3 men with lung changes showed: 425, 480 and 680 µg/l

- in a men with pneumoconiosis who retired at the age of 65 years urine level was 55 µg/l 7 month later and 28 µg/l 4 years later

(there was no detectable diminution in the lung changes over this period)

This study indicates that work in various smelting processes in the production of antimony trioxide and pure metal is connected with dermatitis in warm weather.

Applicant's summary and conclusion

Conclusions:

This study indicates that work in various smelting processes in the production of diantimony trioxide and the pure metal is connected with dermatitis in warm weather.