Registration Dossier
Registration Dossier
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EC number: 202-612-5 | CAS number: 97-85-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The study was conducted well before GLP or OECD guidelines. Documentation is very limited, but the study was conducted at a leading laboratory to the state of the art at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Isobutyl isobutyrate
- EC Number:
- 202-612-5
- EC Name:
- Isobutyl isobutyrate
- Cas Number:
- 97-85-8
- Molecular formula:
- C8H16O2
- IUPAC Name:
- 2-methylpropyl 2-methylpropanoate
Constituent 1
Test animals
- Species:
- guinea pig
Administration / exposure
- Type of coverage:
- occlusive
- Details on dermal exposure:
- IBIB was applied to skin under a gauze pad and occlusive covering with a rubber cuff.
- Duration of exposure:
- 24 hours
- Doses:
- 5 or 10 cc/kg
- Details on study design:
- The test article was applied for 24 hours under an occlusive rubber cuff. After removal the test subjects were observed for 2 weeks.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 10 other: cc/kg
- Based on:
- test mat.
- Mortality:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 was > 10 cc/kg
- Executive summary:
The dermal LD50 was > 10 cc/kg
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