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Diss Factsheets
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EC number: 274-092-8 | CAS number: 69709-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-08-14 to 1991-08-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Qualifier:
- according to guideline
- Guideline:
- other: The Japanese Regulations for the Carriage and storage of Dangerous Goods by Ships” Notification No. 623 of Ministry of Transport
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N,N',N'-tetramethyl-N''-[3-(trimethoxysilyl)propyl]guanidine
- EC Number:
- 274-092-8
- EC Name:
- N,N,N',N'-tetramethyl-N''-[3-(trimethoxysilyl)propyl]guanidine
- Cas Number:
- 69709-01-9
- Molecular formula:
- C11H27N3O3Si
- IUPAC Name:
- N,N,N',N'-tetramethyl-N''-[3-(trimethoxysilyl)propyl]guanidine
- Reference substance name:
- N,N,N',N'-tetramethyl-N" -[3-(trimethoxysilyl)propyl]guanidine
- IUPAC Name:
- N,N,N',N'-tetramethyl-N" -[3-(trimethoxysilyl)propyl]guanidine
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese white rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 12 weeks
- Weight at study initiation: 2.07 - 2.15 kg
- Housing: no data
- Diet: no data
- Water: no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied:0.5 ml - Duration of treatment / exposure:
- 4 minutes, 60 minutes, 4 hours
- Observation period:
- Assessment of reactions was carried out at 4 minutes, 60 minutes and 4 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 3 sites, not specified
- % coverage: no data
- Type of wrap if used: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Erythema or oedema
- Basis:
- other: 3 animals
- Time point:
- other: 3 minutes
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: No erythema or oedema was observed in any animal at 3 minutes. No scoring system was used in this study.
- Irritation parameter:
- other: necrosis
- Basis:
- other: 3 animals
- Time point:
- other: 60 minutes
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: Necrosis was observed in two out of three animals at 60 minutes. No scoring system was used in the study.
- Irritation parameter:
- other: slight erythema
- Basis:
- other: 3 animals
- Time point:
- other: 60 minutes
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: very slight erythema was observed in one out of three animals at 60 minutes. No scoring system was used in the study.
- Irritation parameter:
- other: slight oedema
- Basis:
- other: 3 animals
- Time point:
- other: 60 minutes
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: very slight oedema was observed in two out of three animals at 60 minutes. No scoring system was used in the study.
- Irritation parameter:
- other: necrosis
- Basis:
- other: 3 animals
- Time point:
- other: 4 hours
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: Necrosis was observed in all three animals at 4 hours. No scoring system was used in the study.
- Irritation parameter:
- other: slight oedema
- Basis:
- other: 3 animals
- Time point:
- other: 4 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: very slight oedema was observed in two out of three animals at 4 hours. No scoring system was used in the study.
- Irritant / corrosive response data:
- Following application for 60 minutes, necrosis was observed in 2 out of the maximum 3 animals. When the test material is applied for 4 hours, necrosis was observed in 3 out of the maximum 3 animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Based on the available data, 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, is reported to be corrosive to the skin, in a study conducted according to an OECD guideline, but not in compliance with GLP. Applying the criteria of Regulation (EC) No 1272/2008, classification sub-category 1B is applicable because necrosis was observed in 2/3 animals after exposure for 1 hour, and 3/3 animals after exposure for 4 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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