Ethyl decanoate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Category approach

Justification for type of information:

See attached report in Section 0 "Categories" or Section 13 "Assessment reports" for justification and rationale of the category approach

Key result

Duration:

18 h

Dose descriptor:

EC50

Effect conc.:

> 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Table 1: Results from available key studies on the source substances of the category

Common name	CAS	Fatty acid chain length	Type of alcohol	MW	Appareance	Toxicitytomicroorganisms
Ethyl decanoate	110-38-3	C10	ethanol	200.32	Liquid	No data
Ethyl undecylenate	692-86-4	C11	ethanol	212.33	liquid	No data
Isopropyl laurate	10233-13-3	C12	Isopropanol	242,41	Liquid	no data
Octyl octanoate	2306-88-9	C8	octanol(C8)	256,42	Liquid	no data
Isopropyl myristate	110-27-0	C14	Isopropanol	270,46	Liquid	Experimental result: EC50(18h) > 10 mg/L (nominal)
Dodecanoic hexylester	34316-64-8	C12	Hexanol(C6)	284,49	Liquid	no data
Ethyl linoleate	544-35-4	C18:2	ethanol	308,5	Liquid	no data
Ethyl oleate	111-62-6	C18:1	ethanol	310.52	Liquid	no data
2-ethylhexyl laurate	20292-08-4	C12	2-Ethyl-Hexanol	312,53	Liquid	no data
Fatty acids, coco, 2-ethylhexyl esters	92044-87-6	C12-14	2-ethylhexanol	312.53 – 340.60	liquid	No data

 

Based on the category approach and the available study on Isopropym myristate, the EC50 on the growth of Pseudomonas putida was derived as greater than 10 mg/L (nominal) after 18 hours exposure. The ready biodegradability observed for the category members also demonstrated that these substances show no adverse effects to micro-organisms.

Validity criteria fulfilled:

yes

Conclusions:

Based on the category approach, the 18h-EC50 of the target substance "Ethyl decanoate" on the growth of Pseudomonas putida was estimated as > 10 mg/L (nom.).

Executive summary:

According to the Regulation (EC) NO. 1907/2006, Annex XI, 1.5, A read-across category was performed in order to provide informations on ethyl decanoate CAS 110-38-3.

This category was based on common and shared properties as:

- common functional group,

- common precursors and the likelihood of common impurities resulting from common process of manufacturing,

- chemically structurally similar breakdown products obtained via the same biological processes into the organisms, and

- constant pattern in the changing of the potency of the properties across the category.

One study was available to assess the toxicity of Isopropyl myristate to microorganisms. The EC50 on the growth of Pseudomonas putida was derived as greater than 10 mg/L (nominal) after 18 hours of exposure. Moreover the ready biodegradability observed for the category members also demonstrates that these substances showed no adverse effects to micro-organisms.

Based on the category approach, the 18h-EC50 of the target substance Ethyl decanoate to the growth of Pseudomonas putida was derived as greater than 10 mg/L (nominal).

Description of key information

Based on the category approach, the 18h-EC50 of the target substance Ethyl decanoate on the growth of Pseudomonas putida was estimated as > 10 mg/L (nom.).

Key value for chemical safety assessment

EC50 for microorganisms:

10 mg/L

Additional information

Justification and rationale of the category approach for Ethyl decanoate

This category group covers fatty acid chains linked to alcohols via an ester function. It includes mono-constituent substances and UVCB substances with varying fatty acid chain lengths from C8 to C18-unsaturated and alcohol types (including ethanol, isopropanol, octanol, hexanol and 2-ethylhexanol). This category group was made in order to provide sufficient information for physico-chemical, environmental, ecotoxicological and toxicological characterization of ethyl decanoate (CAS 110-38-3). Some data on the target substance of the category are available

This category includes:

-       Target substance:

o       Ethyl decanoate (CAS 110-38-3)

-       Source substances:

o       Ethyl undecylenate (CAS 692-86-4)

o       Isopropyl laurate (CAS 10233-13-3)

o       Octyl octanoate (CAS 2306-88-9)

o       Isopropyl myristate (CAS 110-27-0)

o       Dodecanoic hexyl ester (CAS 34316-64-8)

o       Ethyl linoleate (CAS 544-35-4)

o       Ethyl oleate (CAS 111-62-6)

o       2-Ethylhexyl laurate (CAS 20292-08-4)

o       Fatty acids, coco, 2-ethylhexyl esters (CAS 92044-87-6)

Summary of available studies

Isopropyl myristate CAS 110 -27 -0

In the key study, the acute toxicity of Isopropyl myristate to Pseudomonas putida was tested according to a national guideline (DIN 38412 -8) and GLP. Nominal test substance concentrations ranged from 0.004 to 18 mg/L. After an incubation time of 18 hours, no real toxicity threshold could be determined, since all the measured extinction values were very close to the reference. An EC50(18h) > 10 mg/L was stated.

Moreover the ready biodegradability observed for the category members also demonstrates that these substances showed no adverse effects to micro-organisms.

Conclusion

Based on the category approach, the 18h-EC50 of the target substance "Ethyl decanoate" to the growth of Pseudomonas putida was derived as greater than 10 mg/L (nominal).