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Diss Factsheets
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EC number: 204-029-1 | CAS number: 113-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistance
Abiotic Degradation - A photolysis study was conducted with MGK 264. The data generated during this study demonstrate that [14C]-MGK 264 in aqueous solution at pH 7, 25°C, and exposed to light for 30 days does not photolyze. Because of the lack of degradation, the rate constant was determined to be statistically not significantly different from 0, yielding an infinite half-life.
Biotic degradation - An OECD 301B ready bioavailabilty study is available for MGK 264. Mean cumulative CO2 production by mixtures containing MGK 264 was negligible and had achieved, at most, 3% of the theoretical value (ThCO2,110.1 mg CO2) by the end of the test on Day 29. Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within 10 days of the level achieving 10%. MGK 264 cannot, therefore, be considered to be readily biodegradable.
In addition to the ready bioavailability study, a 365 day aerobic soil metabolism study and a 90 day anaerobic soil metabolism study are available for MGK 264. The average half-lives of MGK 264 was 341 days and 270 days in the aerobic and anaerobic metabolism studies respectively, thus fulfilling the criteria for persistent and also for vP.
The results of these 3 studies show that MGK 264 may be considered to fulfil the criteria for both P and vP based on the lack of biodegradability and the 341 day (worst case) soil DT50 result.
Bioaccumulation
A bioconcentration or bioaccumulation study in aquatic species is not available, however results estimated by QSAR in accordance with Section 1.3 of Annex XI may be used. The QSAR value for MGK 264 using epiwin, BCFBAF v3.01, gives a worst case result of 528. Thus, the criteria for bioaccumulation is not fulfilled.
Toxicity
There is an extensive data set for toxicity of MGK 264 which includes rat and mouse carcinogenicity studies, developmental toxicity studies in rat and rabbit and a reproductive toxicity study in the rat. From the results of these investigations MGK 264 is not classified with respect to carcinogenicity, reproduction or specific organ toxicity and therefore does not fulfil the criteria for T.
Three short term toxicity studies in fish, a short term toxicity study in daphnia and an algal growth inhibition study are available for MGK 264. The lowest 96 -hour LC50 was found in a toxicity study in rainbow trout (under static conditions) and the LC50 was 0.1687 mg/L. Therefore none of the available studies fulfil the criteria of EC50 or LC50 < 0.01 mg/L or <0.1 mg/L and therefore do not meet the criteria of T for aquatic toxicity.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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