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Diss Factsheets
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EC number: 220-668-9 | CAS number: 2855-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.007 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 75.4 mg/L
- Assessment factor:
- 10
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.36 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.136 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.482 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Additional information
Studies with 1,2,4 -Trivinylcyclohexane are available for the trophic levels fish, daphnia, algae and aquatic microorganisms. In the acute toxicity tests, toxic effects in fish were observed. The EC50 for Daphnia magna has been determined >15.4 mg/L and in an algae toxicity test an ErC50 and an ErC10 >1.98 mg/L have been measured. Although, methodological limitations, the acute fish test has been used to derive the PNECintermittend release in a worst case approach. The PNEC freshwater has been derived based on the results of the chronic study with invertebrates applying an assessment factor of 100 because the value is the lowest of the two available long-term results covering two trophic levels (algae and invertebrates) in accordance to the ECHA guidance document R.10 (2008). The calculation of the PNEC for STP has been based on the available oxygen consumption test with P. putida, in which an EC10 of 754 mg/L has been measured. The assessment factor of 10 has been chosen as the test procedure is comparable to a respiration inhibition test.
The PNEC sediment, PNEC sediment marine and the PNEC soil have been derived using the equilibrium partitioning method using the KOC and the Henry’s law constant of the test substance and the PNEC freshwater or PNEC marine water. Further calculation factors, like the conversion factor from wet to dry, were chosen according to the guidance document R. 10 (May 2008). A PNEC air has not been derived as no hazard has been identified. The PNEC for secondary poisoning was not derived due to limited data. However, the test substance is not classified as CMR or STOT RE1 or RE2. Hence a detailed assessment has not been conducted.
Conclusion on classification
Under the tested conditions, 1,2,4-Trivinylcyclohexane has not been observed to be readily biodegradable. Acute studies are available for the trophic levels fish, daphnia, algae and aquatic microorganisms. In an acute toxicity test with zebrafish, a LC50 of 3.2 mg/L has been observed and in a second fish study with substance specific analytic, a LC50 of 0.652 mg/L has been determined. Both results are above the water solubility limit of the test substance. Nevertheless, the toxic effects should be considered for classification and labeling. In a long-term study on daphnia, a NOEC (21 d) for reproduction of 0.0444 mg/L and an EC10 (21 d) for reproduction of 0.0414 mg/L have been determined. A long-term test with fish is not available, in the toxicity test with algae an ErC10 > 1.98mg/L has been observed.
Based on the acute toxicity data, the test substance should be classified as acute toxic for the aquatic compartment, Category 1 (H400) according to CLP regulation (M-factor 1). Based on the chronic data of the study with invertebrates and based on the acute data for fish, a classification as aquatic chronic Category 1 (H410) is required (M-factor 1). The classification according to UN-GHS regulation would result in the same classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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