Registration Dossier
Registration Dossier
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EC number: 426-460-6 | CAS number: 260415-81-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.12 (Mikrokerntest)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- other: mus, NMRI
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Polyethylenglykol 400
- No. of animals per sex per dose:
- Male: 200 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 670 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 2000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 2000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 200 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 670 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 2000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 2000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Results and discussion
- Additional information on results:
- Doses producing toxicity:
Unspecific toxic symptoms at 2000 mg/kg, no deaths; very
slight cytotoxic effec (PCE/NCE) at 2000 mg/kg and 48 h.
No increase of the micronucleus rate in the animals treated
with the substance.
Unspecific toxic symptoms at 2000 mg/kg. No deaths; very
slight cytotoxic effext (PCE/NCE) at 2000 mg/kg and 48 h.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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