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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.

Data source

Reference
Reference Type:
other: QSAR model
Title:
EPI Suite v 4.1/DERMWIN v2.01
Author:
US EPA
Year:
2014
Bibliographic source:
http://epa.gov/oppt/exposure/pubs/episuite.htm

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Using the DERMWIN v2.01 QSAR model
GLP compliance:
no
Remarks:
not applicable to QSAR models

Test material

Constituent 1
Chemical structure
Reference substance name:
O-isobutyl ethylthiocarbamate
EC Number:
259-869-1
EC Name:
O-isobutyl ethylthiocarbamate
Cas Number:
55860-53-2
Molecular formula:
C7H15NOS
IUPAC Name:
O-isobutyl ethylthiocarbamate
Test material form:
liquid
Radiolabelling:
no

Test animals

Species:
other: QSAR model,
Strain:
other: QSAR model,
Sex:
not specified

Administration / exposure

Type of coverage:
other: QSAR model
Vehicle:
other: QSAR model
Duration of exposure:
not applicable to QSAR models
Doses:
not applicable to QSAR models
No. of animals per group:
not applicable to QSAR models
Control animals:
no
Details on study design:
not applicable to QSAR models
Details on in vitro test system (if applicable):
not applicable to QSAR models

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Absorption in different matrices:
A QSAR model predicts that the permeability of O-isobutyl ethylthiocarbamate (IBETC) to human skin is quite low. The permeability coefficient was determined to be 0.00487 mg/cm2, which is around 1% of the skin penetration rate.
Predicted dermally absorbed coefficient was determined to be Kp (est)=00.0663 cm/hr

Any other information on results incl. tables

A QSAR model predicts that the permeability of O-isobutyl ethylthiocarbamate (IBETC)  to human skin is quite low. The permeability coefficient was determined to be   0.00487 mg/cm2, which is around 1% of the skin penetration rate.

Predicted dermally absorbed coefficient was determined to be Kp (est)=00.0663 cm/hr  

Applicant's summary and conclusion

Conclusions:
A QSAR model predicts that the permeability of O-isobutyl ethylthiocarbamate (IBETC) to human skin is quite low. The permeability coefficient was determined to be 0.00487 mg/cm2, which is around 1% of the skin penetration rate.
Predicted dermally absorbed coefficient was determined to be Kp (est)=00.0663 cm/hr
Executive summary:

A QSAR model predicts that the permeability of O-isobutyl ethylthiocarbamate (IBETC)  to human skin is quite low. The permeability coefficient was determined to be   0.00487 mg/cm2, which is around 1% of the skin penetration rate.

Predicted dermally absorbed coefficient was determined to be Kp (est)=00.0663 cm/hr