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Diss Factsheets
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EC number: 235-406-9 | CAS number: 12220-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation potential expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Acid Orange 067 is a orange-red organic powder, dyestuff. It is not toxic/harmful for short-term exposures and it is not skin/eye irritating. It is not able to cause skin sensitization. No genotoxic activity has been observed in specific experiments performed. The Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test did not evidence any reason of concern. Therefore, mechanisms of bioactivation leading to adverse effects are not expected to occur.
There are no specific studies or specific literature data on toxicokinetics and metabolism, thus available information about the substance has been taken into account, avoiding further tests.
Because of the physical state and the characteristic particle size distribution, inhalation is not an appropriate route of exposure.
During the acute oral toxicity experiments, the treatment did not produce changes detected in health condition; faeces were stained orange after one day. During the subacute oral test, yellowish colour of stool was observed in the bedding material of all animals administered with 1000 mg/kg bw/day from Day 6 up to the termination of the study. Since Acid Orange 067 showed a slightly alkaline pH is solution, it may be expected that possible absorption would take place in the intestine, rather than in stomach.
Yellowish colour of the faeces was attributed to the elimination of test item or its metabolite by the gastrointestinal tract. There are some possible reason explaining the fact that only at the highest tested concentration stained stools were observed. For example, a saturation level may had been reached, at the highest tested concentration, so that the organism was not able to further transform/absorb additional amount of substance; however, it may be also due to the substance concentration and colour intensity, which impacted the reading at the lowest dose levels.
Acid Orange 067 has a structure with different chemical groups, which, it is supposed, may undergo to metabolic reactions; however, on the basis of the available information a conclusion cannot be traced, neither from qualitative, either from rate point of view. The only consideration that may be proposed is that, taken into account the absence of significant effects directly attributable to the test item administration and the observed stained faeces, it may be supposed that only few rates of substance can be absorbed or that it can be metabolised into a easily eliminable compound(s), not significantly harmful/toxic. In any case, processes of bioactivation, which may increase the substance toxicity, can be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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