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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1975
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP. Evaluated during a skin absorption study.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008

Materials and methods

Principles of method if other than guideline:
-Principle of test: Acute dermal toxicity was evaluated during a skin absorption study. Two mice were each administered a single 4-hour dermal application of neat fenchyl acetate on the shaved abdominal skin. Observations were made after 4 hours.
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
EC Number:
204-727-6
EC Name:
Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
Cas Number:
125-12-2
Molecular formula:
C12H20O2
IUPAC Name:
(1S,2S,4S) 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No (0/10) deaths were observed.
Clinical signs:
No clinical signs were observed

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The dermal LD50 in rabbit is greater than 5000 mg/kg bw
Executive summary:

The acute dermal LD50 for fenchyl acetate in rabbits exceeded 5000 mg/kg based on no (0/10) deaths at that dose. Ten rabbits each received a single dermal application of neat test material. Animals were observed for 14 days. No clinical signs were observed.