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EC number: 234-433-3 | CAS number: 12003-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The solubility of aluminium lanthanum trioxide (AlLaO3) is low since dissolution of AlLaO3 in water resulted in La concentrations < 0.01 mg/L and Al concentrations < 0.03 mg/L after 34 days. The dissolution of AlLaO3 in water results in Al (3+) (=Al(H2O)6 (3+)) ions and La (3+) ions. Thus, the toxicological moieties of concern are aluminium and lanthanum ions. Thus, in the assessment of toxicity, data available for different aluminium and lanthanum substances are read-across since aluminium and lanthanum ions determine the toxicological potential of aluminium lanthanum trioxide, i.e. are the common toxicological moieties of concern. The effects of the substance aluminium lanthanum trioxide with regard to skin irritation are predicted to be equal to the effects of Al (3+) ions and La (3+) ions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : Longer duration of exposure (24 versus 4 hours); no detail on pH of test substance; limited detail on characteristics of the test substance.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium oxide
- EC Number:
- 215-691-6
- EC Name:
- Aluminium oxide
- Cas Number:
- 1344-28-1
- Molecular formula:
- Al2O3
- Details on test material:
- - Name of test material (as cited in study report): ALON (aluminium oxide or fumed alumina)
- Physical state: white powder with faint odour)
- Analytical purity: close to 100%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Age: not reported
Sex: not reported
Weight: not reported
Environmental/Housing conditions:
No information provided.
Acclimation: No information was provided.
Feeding conditions:
This information was not provided.
Test system
- Type of coverage:
- other: wrapped with binders of rubber dam
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
-Concentrations: 0.5g in 1.0mL = 500g/L (50%)
-Volume: 1.0 mL
-Area: the substance was under a 1 inch square patch. - Duration of treatment / exposure:
- A single, 24 hour dermal application was made.
- Observation period:
- Observations were made at 24 and 72 hours.
- Number of animals:
- Three animals with intact skin and three animals with abraded skin
- Details on study design:
- One-inch square gauze patches were applied to pre-moistened, clipped intact or abraded skin on the back of the animals, wrapped with binders of rubber dam and immobilised for the exposure period.
The scoring system used was that of Draize (1959) and was provided in the report:
Evaluation of Skin reactions
Erythema and eschar formation:
No erythema, Score = 0
Very slight erythema (barely perceptible), Score =1
Well-defined erythema, Score=2
Moderate to severe erythema, Score=3
Severe erythema (beet redness) to slight eschar formation (injuries in depth), Score =4
Edema formation:
No edema, Score=0
Very slight edema (barely perceptible), Score=1
Slight edema (edges of area will defined by definite raising), Score=2
Moderate edema (raised approximately 1.0mm)
Severe edema (raised more than 1.0mm extending beyond the area of exposure), Score=4
-“Values for erythema and eschar formation at 24 hours and 72 hours for intact skin animals will be added to the values on abraded skin animals at 24 and 72 hours. Similarly, the values for edema formation at 24 hours and at 72 hours for the intact and abraded skin animals will be added. The primary irritant score is the total of the eight values divided by four. A primary irritant is one which results in a score of five or more as tested by this method.”
The pH of the test substance was not measured.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3/3
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Other effects:
- Clinical signs of toxicity were not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results from the study are negative and would not lead to classification.
- Executive summary:
A study conducted at Hazleton Laboratories Inc. for the Cabot Corporation investigated dermal irritation effects of ALON, a fumed alumina produced by the chemical hydrolysis of aluminium chloride, in New Zealand White rabbits. 0.5g of the substance in 1.0mL of distilled water was applied to pre-moistened skin on the backs of 6 rabbits under gauze patches. Three of the rabbits had abraded skin and three intact skin. The patches remained place for 24 hours. Lesions were scored at 24 hours and at 72 hours using the scoring criteria of Draize (1959). The report lacks detail on animal husbandry and signs of toxicity. Further details of the test substance characteristics were obtained from the study sponsor. The results showed slight erythema in all three rabbits with abraded skin at 24 hours. The erythema had resolved by 72 hours. No erythema was observed in the animals with intact skin. No animal exhibited edema. The overall primary irritation score from the study (0.25) would not lead to classification.
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