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EC number: 205-293-0 | CAS number: 137-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute Inhalation toxicity of Metam-sodium (CAS no: 137-42-8) in rat.
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- IFA GESTIS, GESTIS SUBSTANCE Database, 2017
- Reference Type:
- other: authoritative database
- Title:
- Acute Inhalation toxicity of Metam-sodium (CAS no: 137-42-8) in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 008
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2008
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset of Metam-sodium (CAS no: 137-42-8).
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset of Metam-sodium (CAS no: 137-42-8), EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000.
- Reference Type:
- secondary source
- Title:
- Draft Assessment Report (Metam-sodium), ANNEX B.6 Toxicology and metabolism
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 007
- Bibliographic source:
- Draft Assessment Report (Metam-sodium) - Volume 3, Annex B, part 2, B.6, October 2007.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Acute inhalation toxicity of Metam-sodium (CAS no: 137-42-8) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Metam-sodium
- EC Number:
- 205-293-0
- EC Name:
- Metam-sodium
- Cas Number:
- 137-42-8
- Molecular formula:
- C2H5NS2.Na
- IUPAC Name:
- sodium (methylcarbamothioyl)sulfanide
- Details on test material:
- - IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: aqueous formulation containing 42.2% methylcarbamodithionic acid monosodium salt
- Mass median aerodynamic diameter (MMAD):
- 2.6 µm
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- not specified
- Concentrations:
- 6.8 mg/L (6800 mg/m3)
- No. of animals per sex per dose:
- 5 rats/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Animals were observed for mortality, clinical signs and body weight change. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.8 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 6.8 mg/L air (6800 mg/m3)
- Clinical signs:
- other: Clinical signs during exposure animals attempt to escape. Reddish discharge from the nose and discharge from eyes were noted. After inhalation, hair in the genital area was covered with reddish crusts as well as part of the nose covered with reddish crust
- Body weight:
- Body weight gain of male rats was retarded in the first week of observation period but recovered in the second week. Body weight gain of females remained slightly retarded over the total observation period.
- Gross pathology:
- No organ abnormalities were detected.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation LC50 value was considered to be > 6.8 mg/L (>6800 mg/m3), when 10 Wistar rats were treated with Metam-sodium (CAS no: 137-42-8) via inhalation route by aerosol for 4 hours exposure.
- Executive summary:
Acute inhalation toxicity study of Metam-sodium (CAS no: 137-42-8)was conducted according to OECD Guide–line 403 "Acute Inhalation Toxicity"in 10 Wistar rats at the concentration of 6.8 mg/L (6800 mg/m3). The rats were exposed to metam sodium (batch n° ZH 130 585, 42.2% aqueous solution) by head-nose to an aerosol air mixture for 4 hours (MMAD 50% = 2.6 μm; 90.1% was respirable). Animals were observed for mortality, clinical signs and body weight change for 7 days. No mortality was observed at 6.8 mg/L air (6800 mg/m3). Clinical signs during exposure animals attempt to escape. Reddish discharge from the nose and discharge from eyes were noted. After inhalation, hair in the genital area was covered with reddish crusts as well as part of the nose covered with reddish crusts. Stepping gait was slightly high and respiration was slightly sound. The poisoning symptoms confirmed the pronounced irritation described above (fully reversible within 7 days). Body weight gain of male rats was retarded in the first week of observation period but recovered in the second week. Body weight gain of females remained slightly retarded over the total observation period. No organ abnormalities were detected. Therefore, LC50 value was considered to be > 6.8 mg/L (>6800 mg/m3), when 10 Wistar rats were treated with Metam-sodium (CAS no: 137-42-8) via inhalation route by aerosol for 4 hours exposure.
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