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EC number: 249-670-8 | CAS number: 29508-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- OPINION ON Basic Red 51 COLIPA n° B116
- Author:
- Scientific Committee on Consumer Products – SCCP
- Year:
- 2 011
- Bibliographic source:
- Scientific Committee on Consumer Products – SCCP, COLIPA n° B116, during the 10th plenary meeting of 22 March 2011
- Reference Type:
- secondary source
- Title:
- OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING BASIC RED 51
- Author:
- Scientific Committee on Consumer Products – SCCP
- Year:
- 2 003
- Bibliographic source:
- Scientific Committee on Consumer Products – SCCP, during the 25th plenary meeting of 20 October 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity study of Basic Red 51 (77061-58-6) was performed in rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- yes
Test material
- Reference substance name:
- 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- EC Number:
- 278-601-4
- EC Name:
- 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- Cas Number:
- 77061-58-6
- Molecular formula:
- C13H18N5.Cl
- IUPAC Name:
- 2-[[4-(Dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- Details on test material:
- - Name of test material (IUPAC name): 2-[[4-(Dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- Common name: Basic Red 51
- Molecular formula: C13H18N5.Cl
- Molecular weight: 279.773 g/mol
- Smiles notation: c1([n+](ccn1C)C)\N=N\c1ccc(cc1)N(C)C.[ClH-]
- InChl: 1S/C13H18N5.ClH/c1-16(2)12-7-5-11(6-8-12)14-15-13-17(3)9-10-18(13)4;/h5-10H,1-4H3;1H/q+1;/p-1
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Basic Red 51
- Molecular formula :C13H18N5.Cl
- Molecular weight :279.773 g/mol
- Substance type:organic
- Physical state:Blue to dark violet powder containing lumps
- Purity :97.2%
- Impurities (identity and concentrations):2.8%
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD)IGS BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: distilled water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: It was applied to the clipped area as a thin uniform layer from scapula to iliac crest and half way down the flank on each side of the animal’s back.
Details on exposure:
VEHICLE
- Concentration in vehicle:2000 mg/kg bw
- Justification for choice of vehicle: Test substance was moistened in distilled water
DOSAGE PREPARATION (if unusual): The test material was moistened with distilled water. - Duration of exposure:
- Duration of exposure :24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Total:20 animals
2000 mg/kg bw:10 males and 10 females - Control animals:
- other: yes,Total:20 animals 0 mg/kg bw:10 males and 10 females
- Details on study design:
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: All animals were examined for clinical signs of ill health or mortality immediately post-dose and approximately 1, 2.5 and 4 hours post-dose, and daily thereafter.
- Frequency of weighing:Body weights were recorded pre-dose on the day of dosing (Day 0), and on Days 7 and 14, and prior to sacrifice on Day 15 (fasted)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs,body weight, organ weights - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed at dose 2000 mg/kg bw
- Mortality:
- No mortality was observed at dose 2000 mg/kg bw
- Clinical signs:
- other: Signs of clinical toxicity included chromodacryorrhea and/or red nasal discharge. Findings were first noted 4 hours post-dose and were resolved by Day 2. Signs of dermal irritation included desquamation (slight scaling) in all males on Day 3 and in one m
- Gross pathology:
- A curtailed gross examination of the cervical, thoracic and abdominal viscera was performed.
No visible lesions were noted in any of the animals at necropsy. - Other findings:
- no data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be >2000 mg/kg bw,when rats were occlusively treated with Basic Red 51 (77061-58-6) by dermal application.
- Executive summary:
In acute dermal toxicity study,10 males and 10 females Crl:CD (SD)IGS BR rats were occlusively treated with Basic Red 51(77061-58-6)in the concentration of 2000 mg/kg bw by dermal application following 14 days of observation period. The test material was moistened with distilled water.The untreated skin of each animal served as the control.The hair was clipped the day prior to the experiment. It was applied to the clipped area as a thin uniform layer from scapula to iliac crest and half way down the flank on each side of the animal’s back. The area was occluded for 24 hrs.The initial dermal irritation was scored and recorded 30 minutes after bandage removal on Day 1.No mortality was observed in treated rats at dose 2000 mg/kg bw.Signs of clinical toxicity included chromodacryorrhea and/or red nasal discharge. Findings were first noted 4 hours post-dose and were resolved by Day 2. Signs of dermal irritation included desquamation (slight scaling) in all males on Day 3 and in one male and one female on Day 7. There were no signs of dermal irritation at any observation interval in any of the remaining animals.All animals gained weight during the course of the study. No visible lesions were noted in any of the animals at necropsy.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rats were treated with Basic Red 51(77061-58-6)by dermal application.
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