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EC number: 235-527-7 | CAS number: 12262-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 is 1.08 ml per kg body weight which corresponds to 1242 mg/kg bw (the density is 1.15). From the results of an acute inhalation study it is concluded that the 4-hour LC50 of, Cyclonox LE-50 is higher than 5.0 ppm (>29 mg/m3). The study is not suitable fro C&L. Only one concentraton was tested and the test atmsphere was based on the maximum attainable concentration by evaporation at 22 degrees celcius. There is no acute dermal toxicity study. According to REACH Annex VIII column II acute studies do not need to be conducted when 'the substance is classified as skin corrosion'
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited details; no COA; non-GLP. Needs test article id statement
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (Wistar-derived) from the Institute's colony were used. The body weights of males varied from 247 to 345 g, those of females from 146 to 249 g. The rats were housed in groups of five in screen-bottomed stainless steel cages in a well-ventilated room, maintained at 23-25 degs C. Before dosing the rats were fasted overnight.
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- After some preliminary observations, the test material was given by gavage as a 10 % (v/v) dilution in propylene glycol to groups of five males and five females in single doses of 6.94, 8.33, 10.0 or 12.0 ml per kg body weight. After treatment the rats received stock diet and tap water ad
libitum. They were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors. - Doses:
- 0.96, 0.83, 1.00, 1.2 ml/kg test material
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- The LD50 was calculated according to the method of Weil (Biometrics 8 (l952) 249-263).
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.08 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.02 - <= 1.15
- Mortality:
- See table.
- Clinical signs:
- other: Within a few hours after dosing the rats showed sluggishness and humpback behaviour. Unconsciousness was frequently observed and preceded death. Deaths occurred between 7 and 23 hours after treatment. Thereafter, the survivors recovered gradually and look
- Gross pathology:
- Macroscopic examination of the survivors revealed no treatment-related gross alterations.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- From the mortality figures the LD50 was calculated to be 1.08 ml per kg body weight with 1.02 and 1.15 as the 95 % confidence limits.
- Executive summary:
The acute LD50 was determined following the oral gavage administration of the test substance to groups of five males and five females in single doses of 6.94, 8.33, 10.0 or 12.0 ml per kg body weight. Animals were observed for 14 days following administration for clinical signs of toxicity and mortality. The LD50 was calculated to be 1.08 ml per kg body weight with 1.02 and 1.15 as the 95 % confidence limits.
Reference
The density is 1.15.
The LD50 was calculated to be 1.08 ml per kg body weight which corresponds to 1242 mg/kg bw.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 242 mg/kg bw
- Quality of whole database:
- K2 study
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adequate details; non-GLP; no COA; no analytical data but test atmospher analyzed.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (SPF· reared, Wistar-derived) were used as the experimental animals. The weight of the males was 195-205 g, that of the females 135-145 g. The rats were obtained from the Central Institute for the Breeding of Laboratory Animals. TNO, Zeist, The Netherlands.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: Filtered air
- Details on inhalation exposure:
- The exposure chamber used consisted of a horizontally placed-glass cylinder (0.90 x 0.15 m) with sampling ports on both ends and containing stainless steel wire screens for separately accommodating the experimental animals.
Analysis of cyclohexanone peroxides, was carried out according to a
method comprising absorption in xylene followed by spectrophoto-
metrical measurement.
The dynamic atmosphere was generated by passing a known amount of
filtered air (relative humidity c.~ 45%) from the compressed air line
through five glass evaporators (1.0 l/min/evaporator). Each evaporator
was laden with Chromosorb W-AW 60/80, saturrated with Cyclonox LE-50.
The temperature of the evaporators during the experiment was 22 deg C. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- The maximum attainable concentration of the peroxide vapours in the test atmosphere was 5.0 ppm.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- One group of five males and five females was used. After exposure (4 hours), the animals were returned to their living cages and provided with stock diet and tap water ad libitum for an observation period of 14 days.
- Statistics:
- No applicable.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 ppm
- Exp. duration:
- 4 h
- Mortality:
- There were no mortalities
- Clinical signs:
- other: During the first five minutes of exposure the rats were slightly restless. However, this symptom gradually disappeared and after a quarter of an hour all rats were quiet and asleep. This situation continued thoughout the remainder of the exposure period.
- Body weight:
- No data
- Gross pathology:
- No data
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- From the results of the present acute inhalation study it is concluded that the 4-hour LC50 of, Cyclonox LE-50 is higher than 5.0 ppm (>29 mg/m3). The study is not suitable for C&L. Only one concentraton was tested and the test atmosphere was based on the maximum attainable concentration by evaporation at 22 degrees celcius.
- Executive summary:
The acute inhalation toxicity of Cyclonox LE-50 was studied by exposing rats for four hours to the vapour of this substance at the highest concentration attainable.
At 5.0 ppm; which is the highest peroxide concentration possible under the experimental conditions, no mortality or signs of intoxication were observed.
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- K2 study
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on an oral LD50 of 1242 mg/kg bw the substance is classified in Acute Tox. 4 as harmful if swallowed.
The acute inhalation study is not suitable for C&L and there is no acute dermal study.
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