Registration Dossier
Registration Dossier
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EC number: 270-846-5 | CAS number: 68478-97-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 74.5 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- > 24 - < 144 h
- Temp.:
- 20 °C
- pH:
- 4.6
- Details on results:
- On completion of the equilibration period, all main test sample solutions were hazy, yellow and contained undissolved test item. The solutions were decanted, centrifuged and filtered. Each filtrate was visually observed to be clear, yellow and free from undissolved test item.
It was noted that the analysis of the matrix blank solution produced some peaks in both main test sequences, representing approximately 15% of the response of samples 1 to 3 and approximately 8% of the response of samples 4 to 6. The blank response was rejected from the calibration curve, since it had a detrimental effect on the fit of the trend line. However, it has to be noted that, for each sequence, the matrix blank response affected equally the chromatography of the standards and the samples; therefore, it can be considered that its overall effect on the analysis results was negligible.
The water solubility results from samples 1 to 3 indicated an increase in concentration with shaking time; therefore, three extra samples were prepared using longer equilibration times to ensure saturation. The mean result from samples 4 to 6 has been given as the overall water solubility result. The individual water solubility results from samples 4 to 6 were within ± 15% of the mean, satisfying the criteria specified in the guidelines. - Conclusions:
- The water solubility of the test item has been determined to be 74.5 g/L of solution at 20.0 ± 0.5 °C. The test item was also determined to be miscible with water at any proportion equal or greater than 50% w/w.
- Executive summary:
The water solubility of the test item has been determined to be 74.5 g/L of solution at 20.0 ± 0.5 °C. The test item was also determined to be miscible with water at any proportion equal or greater than 50% w/w.
Reference
Description of key information
The water solubility of the test item has been determined to be 74.5 g/L of solution at 20.0 ± 0.5 °C. The test item was also determined to be miscible with water at any proportion equal or greater than 50% w/w.
Key value for chemical safety assessment
- Water solubility:
- 74.5 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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