Manganese bis(phosphinate)

Endpoint summary

Description of key information

Data available for the similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are as mentioned below:

Study 1

In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.  

Study 2

In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.  

Study 3 

In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally

Thus, based on the above summarised studies, manganese(2+) bis(phosphinate) (10043-84-2) and it’s read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

WoE report is based on three acute oral toxicity studies as-
1,2 and 3. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents’ species rats and mice.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Species:

other: 1.mouse 2.& 3. rats

Strain:

other: 1. Swiss 2.&3. Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

1& 2
Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:20-22g
- Fasting period before study: No data available
- Housing: polycarbonate cages
- Diet (e.g. ad libitum): The animals were fed Gold Mohur Hind Lever diet ad libitum.
- Water (e.g. ad libitum): water ad libitum.

- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24± 0.5°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): a 12 h dark and 12 h
light cycle.

Route of administration:

oral: unspecified

Vehicle:

other: 1&2.de-ionized triple glass distilled water

Details on oral exposure:

1&2.The test material were dissolved in de-ionized triple glass distilled water

Doses:

1.2330mg/kg bw
2.2150 mg/kg bw
3. 2000mg/kg bw

No. of animals per sex per dose:

1 & 2 .
Total :10
0 mg/kg bw: 5
2330mg/kg bw:5

Control animals:

yes

Details on study design:

1&2.The gross behavioural changes were recorded at 30, 60, 120 and 240 min using method of Irwin (1959).10 The changes in rectal temperature were recorded by using the thermocouple probes on Digital precision thermometer-DU-3S (ELLAB, DENMARK).

Statistics:

No data available

Preliminary study:

No data available

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 - <= 2 330 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed in treated mouse at 2330mg/kg bw.

Mortality:

1.& 2. 50% mortality was observed in treated mouse at 2330 and 2150mg/kg bw.
3. No mortality at 2000mg/kg bw was observed

Clinical signs:

other: 1.& 2.Behavioral changes like somnolence (general depressed activity), convulsions or effect on seizure threshold were observed

Gross pathology:

no data available

Other findings:

no data available

Interpretation of results:

other: Not classified

Conclusions:

The test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic atleast in the dose range of 2000-2330 mg/kg bw.

Executive summary:

Data available for the similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are as mentioned below:

Study 1

In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.  

Study 2

In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.  

Study 3 

In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally

 

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 330 mg/kg bw

Quality of whole database:

Data from Authoritative database

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Data available for the similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are as mentioned below:

Study 1

In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.  

Study 2

In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.  

Study 3 

In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally.

Thus, based on the above summarised studies, manganese(2+) bis(phosphinate) (10043-84-2) and it’s read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.

Justification for classification or non-classification

Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.