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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs - CARYOPHYLLENE ACETATE.
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Vol. 12, Pg. 839, 1974.
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat.
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012.
Reference Type:
other: Authoritative database
Title:
Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
Reference Type:
secondary source
Title:
Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in rat
Author:
U.S. Environmental Protection Agency, Chemistry Dashboard
Year:
2018
Bibliographic source:
Chemistry Dashboard, U.S. Environmental Protection Agency, 2018.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- InChI: 1S/C17H28O2/c1-12(18)19-17-8-5-7-16(4,11-17)9-6-13-14(17)10-15(13,2)3/h13-14H,5-11H2,1-4H3/t13-,14+,16+,17-/m1/s1
- Smiles: CC(=O)O[C@@]12CCC[C@@](C)(CC [C@@H]3[C@@H]1CC3(C)C)C2
- Common Name of test material :Caryophyllene acetate
- Molecular formula:C17H28O2
- Molecular weight:264.4062 g/mol
- Substance type: Organic
- Physical state: Colorless slightly viscous liquid with a mild fruity woody odor.
Specific details on test material used for the study:
- IUPAC Name: [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- InChI: 1S/C17H28O2/c1-12(18)19-17-8-5-7-16(4,11-17)9-6-13-14(17)10-15(13,2)3/h13-14H,5-11H2,1-4H3/t13-,14+,16+,17-/m1/s1
- Smiles: CC(=O)O[C@@]12CCC[C@@](C)(CC [C@@H]3[C@@H]1CC3(C)C)C2
- Common Name of test material :Caryophyllene acetate
- Molecular formula:C17H28O2
- Molecular weight:264.4062 g/mol
- Substance type: Organic
- Physical state: Colorless slightly viscous liquid with a mild fruity woody odor.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at 5000 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be >5000 mg/kg bw, when rats were treated with [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) via oral route.
Executive summary:

Acute oral toxicity study of[1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) was conducted in rats at the concentration of 5000 mg/kg bw. No mortality was observed in treated rats at5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw, when rats were treated with[1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate via oral route.