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EC number: 205-521-9 | CAS number: 142-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Referring to "Appraisal of the safety of chemicals in foods, drugs and cosmetics" by the Staff of the Division of Pharmacology, FDA, 1959
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- "Appraisal of the safety of chemicals in food, drugs and cosmetics", by the staff of the Division of Pharmacology; FDA, 1959
- Principles of method if other than guideline:
- The test item was applied undiluted via gavage once at test start.
Prior to administration of the test item, the animals were not fed for 16 hours.
The administration was followed by a observation period of 14 days.
Afterwards an necropsy was performed.
The test item is a clear liquid with a pH value of 6.0. - GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- hexyl 2-methylprop-2-enoate
- EC Number:
- 205-521-9
- Cas Number:
- 142-09-6
- Molecular formula:
- C10H18O2
- IUPAC Name:
- hexyl 2-methylprop-2-enoate
- Test material form:
- liquid
- Details on test material:
- Commercial grade assumed (~98%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Paderborn
- Females (if applicable) nulliparous and non-pregnant: [yes/no] not specified
- Age at study initiation: not specified
- Weight at study initiation: 150 - 230 g
- Fasting period before study: 16 h
- Housing: individual housing
- Diet (e.g. ad libitum): ad libitum; Ssniff/ Intermast
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Humidity (%): 45 -55 %
- Air changes (per hr): not applicable
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: no vehicle
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg
- Doses:
- 20 mL/kg = 17,720 mg/kg (density: 0.885 g/cm³)
- No. of animals per sex per dose:
- 10 male
10 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality: listed after 1, 2, 5, 7, 14 days; observations : 20 min, 1h, 3h, 24h, 7d, 14d; weighing at test start and termination (14 days)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs; observations : 20 min, 1h, 3h, 24h, 7d, 14d
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 17 720 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: LD50: approx. 20 mL/kg bw (8 of 20 animals were dead after 14 days of observation
- Mortality:
- 24h: 0/20
14d: 8/20 (8 days after administration) - Clinical signs:
- other: Reduced activity, disturbed coordination, hyperthermia, diarrhea, piloerection
- Gross pathology:
- Deceased animals had a gastrointestinal flush.
Sacrificed animals showed no macroscopic anomalies.
Any other information on results incl. tables
The LD50 > 20 ml/kg bw equals to 17720 mg/kg bw(density 0.886 g/cm³)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the test result: LD50 (14days / >17720 mg/kg bw): > 5000 mg/kg bw the test substance n-Hexyl methacrylate has to be classified as practically nontoxic in rats in respect of its acute oral toxicity.
- Executive summary:
In an acute oral toxicity study ( According to the "Appraisal of the safety of chemicals in foods, drugs and cosmetics", by the Staff of the Division of Pharmacology, FDA, 1959)
groups of ten male and ten female SPF-Wistar rats (weight: 150 to 230 g) were given a single oral dose of 20 ml/kg n-Hexylmethacrylate. Animals were then observed for 14 days.
Oral LD50 Combined: > 20 mL/kg (equals to >17720 mg/kg (density 0.886 g/cm3))
8 of 20 animals died within the first 8 days after administration of the test item. These animals showed a gastrointestinal flush. The sacrificed animals instead showed no macroscopic anomalies. The average bodyweight rose from 197.50 g to 228.18 g per animal.
n-Hexyl methacrylate led to a reduced activity, disturbed coordination, hyperthermia, diarrhea and piloerection 20 minutes after the administration. These symptoms were vanished after 24 hours and the surviving animals showed a normal behavior.
n-Hexyl methacrylate is of very low oral toxicity based on this LD50test in males and females.
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