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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
determination of pH value and acid reserve
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Principles of method if other than guideline:
Electrochemical determination of pH value and determination of acid reserve via titration.
GLP compliance:
no
Remarks:
not required for this type of test

Test material

Constituent 1
Chemical structure
Reference substance name:
Gadolinium trinitrate
EC Number:
233-437-2
EC Name:
Gadolinium trinitrate
Cas Number:
10168-81-7
Molecular formula:
Gd(NO3)3
IUPAC Name:
gadolinium trinitrate
Details on test material:
No information on test material.

Test animals

Species:
other: not applicable
Strain:
other: not applicable
Details on test animals or test system and environmental conditions:
not applicable

Test system

Type of coverage:
other: not applicable
Preparation of test site:
other: not applicable
Vehicle:
other: not applicable
Details on study design:
pH-value determination:
The pH-value of a 10% solution (or slurry) is determined electrochemically at 20 °C with a calibrated pH meter (MA 235 Mettler Toledo).

Determination of acid reserve titration:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20 °C, is recorded.

Calculations:
- Titration of the 10% solution/slurry
- Acid reserve = titration volume (mL) x 0.4

Criterion for corrosivity: a product is classified as corrosive if: pH - 1/12 acid reserve <= -0.5

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: pH
Score:
2.7
Remarks on result:
other: Based on the results of a pH/acid reserve determination, the substance is considered not to be corrosive. pH was 2.7 and acid reserve 0.05. Corrosivity calculation = 2.7.
Irritation parameter:
other: acid reserve
Score:
0.05
Remarks on result:
other: Based on the results of a pH/acid reserve determination, the substance is considered not to be corrosive. pH was 2.7 and acid reserve 0.05. Corrosivity calculation = 2.7.
Irritation parameter:
other: corrosivity calculation
Score:
2.7
Remarks on result:
other: Based on the results of a pH/acid reserve determination, the substance is considered not to be corrosive. pH was 2.7 and acid reserve 0.05. Corrosivity calculation = 2.7.
Irritant / corrosive response data:
not corrosive

Applicant's summary and conclusion

Interpretation of results:
other: not corrosive following CLP guidance
Conclusions:
The pH value of a 10% solution of gadolinium trinitrate was determined to be 2.7 and the acid reserve was 0.05. Based on these data, the calculation for corrosivity was 2.7. Therefore the substance was considered not to be corrosive.