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Diss Factsheets
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EC number: 916-329-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 May 2016 to 12 May 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- January, 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- May, 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Test temperature:
- 30 ºC
- Details on study design: HPLC method:
- TEST SYSTEM
The determination was carried out using an HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test system utilized a high performance liquid chromatograph and a cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties.
PREPARATION OF THE TEST SAMPLE SOLUTION
Test item (0.2501 g) was diluted to 50 mL with methanol to give a concentration of 5.00E+03 mg/L.
PREPARATION OF THE DEAD TIME SOLUTION
The dead time was determined by measuring the retention time of formamide (purity* 99.94%, 613 mg/L solution in a matrix of methanol: water (55:45 v/v)).
PREPARATION OF THE REFERENCE ITEM SOLUTIONS
Solutions of reference items (see following table) were prepared in methanol.
Reference Item Purity (%)* Concentration (mg/L)
Acetanilide 99+ 120
Atrazine 99.1 107
Phenol 99.9 143
Isoproturon >98.0 163
Triadimenol 98.0 106
Linuron 99.7 100
Naphthalene 99+ 114
Endosulfan-diol 99.9 160
Fenthion 97.9 152
α-Endosulfan 99.6 101
Phenanthrene ≥99.5 125
Diclofop-methyl 99.1 133
DDT 98.7 144
* value quoted by supplier
DETERMINATION OF RETENTION TIME
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
- HPLC System: Agilent Technologies 1100 series, incorporating autosampler and workstation
- Column: Luna CN 5μm (150 x 4.6 mm id)
- Column temperature: 30 ºC
- Mobile phase: methanol: water (55:45 v/v)
- pH of mobile phase: 6.9
- Flowrate: 1.0 mL/min
- Injection volume: 10 μL
- Method of detection: UV at 210 nm for the deadtime and reference standards UV at 265 nm for the test item
CONSTRUCTION OF CALIBRATION CURVE
A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. Each capacity factor (k') was calculated. A correlation of log k' versus log Koc of the reference standards was plotted using linear regression.
ADSORPTION COEFFICIENT
The capacity factor for each test item solution injection was calculated and the log10 Koc values determined, with reference to the calibration curve. The adsorption coefficient was calculated. - Key result
- Type:
- log Koc
- Value:
- 3.01 dimensionless
- Remarks on result:
- other: Average of 2 constituents
- Type:
- Koc
- Value:
- > 860 - < 1 200 dimensionless
- Remarks on result:
- other: based on 2 constituents
- Type:
- log Koc
- Value:
- > 2.94 - < 3.08 dimensionless
- Remarks on result:
- other: Based on 2 constituents
- Details on results (HPLC method):
- ADSORPTION COEFFICIENT OF THE SAMPLE
The retention times, capacity factor and log10 Koc value determined for the sample are shown in the table under 'Any other information on results incl. tables'. The Log10 Koc for one peak is 2.94 and for the other peak 3.08 (Adsorption coefficients are 860 and 1.20E+03)
pH CONSIDERATIONS
In the absence of any relevant dissociating functional groups, no specific manipulation of the mobile phase pH was necessary to achieve an unionized form of the test item. Therefore the determination was performed at an unadjusted, approximately neutral pH. - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient, log Koc is 3.01 an average of two peaks reflecting the two constituents of the substance.
- Executive summary:
The adsorption coefficient of Floralozone was tested in an HPLC screening method OECDTG 121. The substance showed two peaks one peak of 860 (log Koc 2.94) and another one 1200 (logKoc 3.08). It is not clear which peak belongs to which constituent, therefore an average is of the two values will be used for the risk characterisation: Log Koc is 3.01.
Reference
Table: Retention times, capacity factor and log10 Koc value determined for the sample
Peak |
Injection |
Retention time (mins) |
Capacity Factor (k’) |
Log10 K’ |
Log10 Koc |
Mean Log10 Koc |
Adsorption Coefficient |
1 |
1 |
3.980 |
0.728 |
-0.138 |
2.94 |
2.94 |
860 |
|
2 |
3.975 |
0.726 |
-0.139 |
2.93 |
||
2 |
1 |
4.218 |
0.831 |
-8.03E-02 |
3.08 |
3.08 |
1.20E+03 |
|
2 |
4.213 |
0.829 |
-8.14E-02 |
3.08 |
Description of key information
The adsorption coefficient of Floralozone was tested in an HPLC screening method OECDTG 121. The substance showed two peaks one peak of 860 (log Koc 2.94) and another one 1200 (logKoc 3.08). It is not clear which peak belongs to which constituent, therefore an average is of the two values will be used for the risk characterisation: Log Koc is 3.01.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1 023
Additional information
[LogKoc: 3.01]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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