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EC number: 275-060-6 | CAS number: 70955-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations
- Version / remarks:
- Code of Federal Regulations, Title 16, Section 1500.41.
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
Test material
- Reference substance name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[2-[(4-chloro-6-methoxy-1,3,5-triazin-2-yl)amino]ethyl]amino]sulfonyl sulfo derivs., sodium salts
- EC Number:
- 275-060-6
- EC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[2-[(4-chloro-6-methoxy-1,3,5-triazin-2-yl)amino]ethyl]amino]sulfonyl sulfo derivs., sodium salts
- Cas Number:
- 70955-64-5
- Molecular formula:
- C36.2H18.9Cl0.7CuN11.5O10.2S3.4Na2.7
- IUPAC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[2-[(4-chloro-6-methoxy-1,3,5-triazin-2-yl)amino]ethyl]amino]sulfonyl sulfo derivs., sodium salts
- Test material form:
- solid: particulate/powder
- Details on test material:
- Reactive Blue 71
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- water
- Remarks:
- 0.5 Ml water to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 g test substance was mixed with 0.5 ml of distilled water to form a paste before application to the skin.
- Duration of treatment / exposure:
- test patches were removed after 24 hours.
- Observation period:
- 72 hours
- Number of animals:
- 6 animals
- Details on study design:
- Primary irritation to the skin is measured by a patch test technique on the abraded and intact skin of the albino rabbit, clipped free of hair. A minimum of six subjects are used in abraded and intact skin tests.
Introduce under a square patch such as surgical gauze measuring 1 inch x 1 inch, two single layers thick, 0.5 gram of the test substance.
The animals are immobilized with patches secured in place by adhesive tape. The entire trunk of the animal is then wrapped with an impervious material such as rubberized cloth for the 24-hour period of exposure. This material aids in maintaining the test patches in position and retards the evaporation of volatile substances. After 24 hours exposure, the patches are removed and the resulting reactions are evaluated.
Readings are again made at the end of a total of 72 hours (48 hours after the first reading). An equal number of exposures are made on areas of skin that have been previously abraded. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding. Evaluate the reactions of the abraded skin at 24 hours and at 72 hours. Add the values for erythema and eschar formation at 24 hours and 72 hours for intact skin to the values on abraded skin at 24 hours and 72 hours (four values). Similarly, add the values for oedema formation at 24 hours and at 72 hours for intact and abraded skin (four values). The total of the eight values is divided by four to give the primary irritation score.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 25/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 24/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 24/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 24/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritant / corrosive response data:
- Very slight erythema with and without very slight oedema was observed in the intact and abraded sites of four animals at the 24 hours reading.
Very slight erythema only was observed in the intact and abraded sites of three animals at the 72 hours reading. - Other effects:
- The animals did not show any observable response to treatment throughout the 72 hours observation period.
Any other information on results incl. tables
Numerical scores awarded to the dermal reactions elicited by Procion Turquoise H-A
Rabbit no. |
Reaction |
24 hours |
72 Hours |
||
LEFT Intact |
RIGHT Abraded |
LEFT Intact |
RIGHT Abraded |
||
1 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
0 |
0 |
0 |
0 |
|
2 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
1 |
1 |
0 |
0 |
|
3 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
4 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
5 |
Erythema |
1 |
1 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
6 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
0 |
0 |
0 |
0 |
Primary irritation index = 0.7
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Procion Turquoise H-A is considered to be "mildly irritating" to rabbit skin.
Very slight erythema with and without very slight oedema was observed in the intact and abraded sites of four animals at the 24 hours reading. Very slight erythema only was observed in the intact and abraded sites of three animals at the 72 hours reading. No readings were taken at the 48 hours time point, however, based on the means of the oedema and erythema readings taken at 24 hours and at 72 hours, the substance is not classified under the CLP Regulation. - Executive summary:
The procedure employed was that prescribed by the Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41.
On this occasion 0.5 g of Procion Turquoise H-A was mixed to a paste with 0.5 ml of distilled water before application to the skin.
Very slight erythema with and without very slight oedema was observed in the intact and abraded sites of four animals at the 24 hours reading.
Very slight erythema only was observed in the intact and abraded sites of three animals at the 72 hours reading.
The animals did not show any observable response to treatment throughout the 72 hours observation period.
The primary irritation index was calculated to be 0.7
CONCLUSION
Procion Turquoise H-A is considered to be "mildly irritating" to rabbit skin.
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