Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 275-203-2 | CAS number: 71119-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 23-04-2016 to 27-04-2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- The test substance is a zwitterionic compound. At any pH value the test substance dissociates. The partition coefficient can therefore not be determined of the non-dissociated compound, as would be required by the guidelines.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 27 July 1995
- Deviations:
- yes
- Remarks:
- The test substance is a zwitterionic compound. At any pH value the test substance dissociates. The partition coefficient can therefore not be determined of the non-dissociated compound, as would be required by the guidelines.
- Principles of method if other than guideline:
- The preliminary partition coefficient (log Pow) was estimated using a preliminary screening test. As the preliminary log Pow was outside of the range of the guidelines no main test was determined.
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -2.36
- Temp.:
- 20 °C
- Remarks on result:
- other: pH was not determined, as it was a preliminary screening test.
- Conclusions:
- The log Pow of the test item was determined to be -2.36.
- Executive summary:
A study was conducted according to OECD 107 and EU Method A.8 to determine the log Pow of the test item. In a preliminary test the log Pow was determined using the solubility of the test item in n-octanol and water. The log Pow was determined to be -2.36. Since the guidelines apply to values between -2 and 4, no further tests were performed.
Reference
The difference between the assumed maximal concentration and the measured concentration of the substance in water corresponds to the concentration of the substance in n-octanol:
Measurement | Assumed maximal concentration [mg/mL]
| Measured concentration in water phase [mg/mL]
| Indirectly determined concentration n-octanol phase [mg/mL]
|
1 | 0.840 | 0.836 | 0.004 |
2 | 0.504 | 0.502 | 0.002 |
The Partition Coefficient was calculated using the formula: Pow= c (n-octanol) / c (water).
Measurement | Pow
| log Pow |
1 | 0.0048 | -2.32 |
2 | 0.0040 | -2.40 |
The mean value of the log Pow was determined by averaging the two measurements as -2.36.
Description of key information
The mean value of the log Pow was determined as -2.36 (reference 4.7-1).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.36
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to OECD 107 and EU Method A.8 to determine the log Pow of the test item. In a preliminary test the log Pow was determined using the solubility of the test item in n-octanol and water. The log Pow was determined to be -2.36. Since the guidelines apply to values between -2 and 4, no further tests were performed.
Additionally, the Partition Coefficient was calculated with the atom/fragment contribution method KOWWIN v1.68 as log Pow = -5.22 (reference 4.7-2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.