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EC number: 214-804-6 | CAS number: 1195-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin sensitization potential of target chemical3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was assessedin various experimental studies which were conducted on guinea pigs and humans for target chemical 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) andits structurally similar read across substancesFenchyl acetate (CAS No: 13851-11-1) and alpha-Fenchyl alcohol (CAS No: 512-13-0). The predicted data usingQSAR toolbox and Danish QSAR databasehas also been compared with the experimental data.Based on the available data for the target and read across substances and applying the weight of evidence approach, it can be concluded that chemical3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) is unable to cause skin sensitization and thus can be considered as not sensitizing. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- A Human maximisation test was carried out in 25 volunteers to determine skin sensitization potential caused by the chemical .
- GLP compliance:
- not specified
- Type of study:
- other: Human maximisation test
- Justification for non-LLNA method:
- No data available
- Specific details on test material used for the study:
- - Name of test material : 3, 3-Dimethyl-8, 9-dinorbornan-2-one
- Common name : 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Molecular formula : C10H16O
- Molecular weight : 152.2354 g/mol
- Smiles notation : C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl : 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid - Species:
- other: Human
- Strain:
- other: Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
- Route:
- intradermal and epicutaneous
- Vehicle:
- petrolatum
- Concentration / amount:
- 4%
- Day(s)/duration:
- No data available
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4%
- Day(s)/duration:
- No data available
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 25
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 4%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- No signs of sensitization were observed.
- Remarks on result:
- no indication of skin sensitisation
- Cellular proliferation data / Observations:
- No signs of sensitization were observed.
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test material Fenchone (CAS No: 1195-79-5) was considered to be not sensitizing to the skin of human volunteers.
- Executive summary:
A Human maximisation test was carried out in 25 volunteers to determine skin sensitization potential caused by the chemicalFenchone (CAS No: 1195-79-5).
Each subject was treated with 4% of Fenchone (CAS No: 1195-79-5) in petrolatum dermally and later observed for any signs of contact allergy.
None of the volunteer showed any signs of contact sensitization. Hence the chemical Fenchone (CAS No: 1195-79-5) wasconsidered to be not sensitizing to theskin of human volunteers.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Various studieshas been investigated for the test chemical3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) to observe the potential for skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in guinea pigs and humans for target chemical3,3-Dimethyl-8,9-dinorbornan-2-one / Fenchone (CAS No: 1195-79-5) and its structurally similar read across substanceFenchyl acetate (CAS No: 13851-11-1) and alpha-Fenchyl alcohol (CAS No: 512-13-0).The predicted data usingDanish QSAR databasethe has also been compared with the experimental data and summarized as below;
The D.L.J. Opdyke {Food and Cosmetics Toxicology 1979, Pages 380–382}carried outaHuman maximisation test in 25 volunteers to determine skin sensitization potential caused by the target chemical3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5). Each subject was treated with 4% of Fenchone (CAS No: 1195-79-5) in petrolatum dermally and later observed for any signs of contact allergy. None of the volunteer showed any signs of contact sensitization. Hence the chemical Fenchone (CAS No: 1195-79-5) wasconsidered to be not sensitizing to theskin of human volunteers.
According to Danish QSAR database , the skin sensitization effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) . Based on estimation, no skin sensitization reactions were observed in guinea Pig and Human. Therefore, 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was considered to be not sensitizing.
The above results were further supported by anotherHuman maximization tests conducted byD.L.J. Opdyke for read across chemicals Fenchyl acetate (CAS No: 13851-11-1) and alpha-Fenchyl alcohol (CAS No: 512-13-0) as below;
In case of Fenchyl acetate (CAS No: 13851-11-1) {Food and Cosmetics Toxicology 1979, Pages 383},maximization testwas conducted on 25 volunteers.Under the test conditions, none of the volunteers had developed any signs of skin sensitization when applied dermally at a dose of 5% in petrolatum. Hence the chemical Fenchyl acetate (CAS No: 13851-11-1) wasconsidered to be not sensitizing to theskin of human volunteers.
In maximization test of alpha-Fenchyl alcohol (CAS No: 512-13-0) {Food and Cosmetics Toxicology 1979, Pages 384–385}, the test chemical was applied on 24 volunteers at a concentration of 4% in petrolatum.
None of the volunteers had developed any signs of skin sensitization. Hence the chemical alpha-Fenchyl alcohol (CAS No: 512-13-0) was considered to benot sensitizing to theskin of volunteers.
Based on the available data for the target chemical, supporting studies and read across substance,it can be concluded thatchemical 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) is unable to cause skin sensitization and considered as not sensitizing . Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The skin sensitization potential of test substance3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) and its structurally similar read across substanceFenchyl acetate (CAS No: 13851-11-1) and alpha-Fenchyl alcohol (CAS No: 512-13-0) were observed in various studies. From the results obtained from these studies it is concluded that the chemical3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) is not likely to cause skin sensitization and hence can be classified as non-skin sensitizer.
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