Registration Dossier
Registration Dossier
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EC number: 271-896-0 | CAS number: 68611-47-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- EC Number:
- 271-896-0
- EC Name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- Cas Number:
- 68611-47-2
- Molecular formula:
- Zn2SiO4:Mn
- IUPAC Name:
- Silicic Acid (H4SiO4), Zinc Salt (1: 2), Manganese-Doped
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97a, TA98, TA100, TA102 and TA1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 0.03, 0.1, 0.3, 1.0, 3.0 and 5.0 mg plate-1.
- Vehicle / solvent:
- DMSO (dimethyl sulfoxide)
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- 2-nitrofluorene
- sodium azide
- cumene hydroperoxide
- other: 2-Aminoanthracene
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: A97a, TA98, TA100, TA102 and TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions and the obtained results, the test substance did not induce mutagenic activity in the strains of Salmonella Typhimurium used in this assay.
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