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EC number: 203-775-5 | CAS number: 110-52-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: authoritative database
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Biodegradation study was conducted for evaluating the percentage biodegradability of test substance.
- GLP compliance:
- not specified
- Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 100 mg/L
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 30 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Improved type for a volatile substance
- Key result
- Parameter:
- other: BOD
- Value:
- 17
- Sampling time:
- 28 d
- Key result
- Parameter:
- other: HPLC
- Value:
- 86
- Sampling time:
- 28 d
- Details on results:
- Test substance undergoes 17% and 86% degradation by using BOD and HPLC parameter, respectively, in 28 days.
The test substance changed partially to form 13 - 14% of Tetrahydrofuran and 80 - 87% of Bromide ion in the test solution. Also, Tetrahydrofuran was partly degraded. A negative value of the biodegradation is shown in parentheses. - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The percentage degradation of test substance was determined to be 17% and 86% by using BOD and HPLC parameter, respectively, in 28 days. Thus, based on percentage degradation (17% by BOD), the test substance was considered to be not readily biodegradable in water.
- Executive summary:
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 100 mg/l and initial test substance conc. used in the study was 30 mg/l.The percentage degradation of test substance was determined to be 17% and 86% by using BOD and HPLC parameter in 28 days. Thus, based on percentage degradation (17% by BOD), the substance was considered to be not readily biodegradable in nature.
Reference
Description of key information
The percentage degradation of test substance was determined to be 17% and 86% by using BOD and HPLC parameter, respectively, in 28 days. Thus, based on percentage degradation (17% by BOD), the test substance was considered to be not readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Experimental key study and supporting predicted data for the test chemical and various supporting studies for its structurally similar read across substance were reviewed for the biodegradation end points which are summarized as below:
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 100 mg/l and initial test substance conc. used in the study was 30 mg/l.The percentage degradation of test substance was determined to be 17% and 86% by using BOD and HPLC parameter in 28 days. Thus, based on percentage degradation (17% by BOD), the substance was considered to be not readily biodegradable in nature.
Estimation Programs Interface Suite (EPI suite) was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical is expected to be not readily biodegradable.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30mg/L and initial test substance conc. used in the study was 100mg/L. The percentage degradation of test substance was determined to be 5% and 1% by using BOD and GC parameter in 28 days. Thus, based on percentage degradation (5% by BOD), the substance was considered to be not readily biodegradable in nature
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