2-furoic acid

Density

Link to relevant study record(s)

Reference

Endpoint:

tap density

Remarks:

Density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014

GLP compliance:

no

Type of method:

pour and tap (for solids)

Key result

Type:

pour density

Density:

0.659 g/cm³

Temp.:

26.2 °C

Remarks on result:

other: at 969.8 hPa pressure

Key result

Type:

tap density

Density:

0.773 g/cm³

Temp.:

26.2 °C

Remarks on result:

other: at 969.8 hPa pressure

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1st Reading	2nd Reading
Method	Test methods: Pour density and tapped density of powders recommended inThe International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	26.5°C	26.0°C
Atmospheric pressure (in hPa)	-	970.7	969.0
Weight of test item(m)		20.100	20.100
Volume of measuring cylinder; readability in g		50ml; 1 ml	50 ml; 1 ml
Volume of test item without tapping (V)		30	31
Volume of test item after tapping ( V1)	After 10 tapping	28	27
	After 50 tapping	27	26
	After 100 tapping	26	26
	After 250 tapping	26	26
	After 500 tapping	-	-
	After 750 tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

 

 

By Pour Density and Tapped Density Method:

 

 

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	= m / V	0.6700	0.6483	0.6591
Tap density of test Item (g/cm³)	= m / V1	0.7730	0.7730	0.7730

Conclusions:

The mean pour density and tapped density of test chemical was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.

Executive summary:

The density of test chemical was determined following OECD Guideline 109 and according to the test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test chemical was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.

Description of key information

In an experimental study from study report, the density of test chemical was determined following OECD Guideline 109 and according to the test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test chemical was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.773

Additional information

In an experimental study from study report, the density of test chemical was determined following OECD Guideline 109 and according to the test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test chemical was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.