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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< -1.17
Temp.:
25 °C
pH:
> 2.42 - < 2.97
Details on results:
Stock Solutions
The stability of Stock Solutions 1, 2, and 3 from which the test solutions were prepared was checked alongside the test solution analysis.
The values obtained were compared with the theoretical concentrations of the solutions.
A value of 1689.58 mg/L (16.8958 mg/L x dilution factor of 100) was determined for Stock Solution 1. Comparison of this value with the theoretical concentration of the solution (1586 mg/L) indicates a 106.5 % recovery.
A value of 820.26 mg/L (16.4051 mg/L x dilution factor of 50) was determined for the diluted Stock Solution 2. Comparison of this value with the theoretical concentration of the solution (793 mg/L) indicates a 103.4 % recovery.
A value of 407.5 mg/L (16.3000 mg/L x dilution factor of 25) was determined for diluted Stock Solution 3. Comparison of this value with the theoretical concentration of the solution (396.5 mg/L) indicates a 102.8 % recovery.
Recoveries obtained show that no significant loss of test material has occurred during testing in the stock solutions, therefore indicating that the test solutions were stable throughout the analysis.
Octanol Layers
The concentrations of test item in the octanol layers were not quantifiable; therefore the value of 5 mg/L used for partition coefficient was a less than value calculated from the lowest standard observed during the analysis.
Due to the use of a less than value for the octanol phase all logP values may overestimate the concentration in the octanol phase and therefore the LogP values were represented as less than values.
Recoveries
Total recoveries of the weight initially added to the shake flask tests were consistently higher than theoretical values. The reason for this is unclear, possibly a matrix effect, however there is no indication of degradation during testing as stock solution recoveries were acceptable.
A logP mean value of < -1.17 was calculated, the individual values obtained are slightly outside the ±0.3 log units considered appropriate for this test (maximum difference is 0.4) but this is impacted by the use of “<” values and is not considered significant.


Conclusions:
The partitions koefficient of 2-Hydroxyethyliminodi(acetic acid) was determined to be logP < -1.17 at 25 C using flast method.
Executive summary:

The partitions koefficient of 2-Hydroxyethyliminodi(acetic acid) was determined to be  logP < -1.17 at 25 C using flast method.

Description of key information

The partitions koefficient of 2-Hydroxyethyliminodi(acetic acid) was determined to be  logP < -1.17 at 25 C using flast method.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.17
at the temperature of:
25 °C

Additional information