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EC number: 214-874-8 | CAS number: 1204-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Surface tension
Administrative data
- Endpoint:
- surface tension
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because based on structure, surface activity is not expected or cannot be predicted
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The substance belongs to the chemical family of anhydrides. Therefore it hydrolyses very rapidly into the corresponding acid if contact with water (or moisture).
Based on the study present under IU point 5.1.2, the parent substance hydrolyses completely in water food simulant at 40 °C in less than 0.5 hour. Also, according to EFSA Opinion in Journal (2004)65, 1-17, analogue trimellitic anhydride hydrolyses within ten minutes by stirring with water at 27 - 30°C to trimellitic acid. The same magnitude of order is anticipated for the present substance trimellitic anhydride chloride in standard test conditions.
Since the study is thus technically not feasible on the parent substance, no surface activity can be predicted on it.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Half-life for hydrolysis:
- 0.5 h
- at the temperature of:
- 40 °C
According to REACH Regulation 1907/2006, Annex VIII Column 2, hydrolysis studies are not necessary for substances that are readily biodegradable. Since trimellitic anhydride mono chloride (TMAC) has been considered to be readily biodegradable (Point 5.2.1) based on a read-across approach, a study of its hydrolysis under a range of pH conditions is not required.
However, a study of the hydrolysis of trimellitic anhydride acid chloride, has been performed in the context of the requirements for substances that may come into contact with food via packaging material. This study examined the behaviour of trimellitic anhydride acid chloride in unbuffered distilled water as a simple food simulant. Trimellitic anhydride acid chloride was found to hydrolyse completely at 40 °C in less than ½ hour to trimellitic acid and hydrogen chloride gas. Hydrolysis of the monomer was virtually instantaneous.
Since trimellitic anhydride mono chloride has been shown to be readily biodegradable (Point 5.2.1), a study of its hydrolysis under a range of pH conditions is not strictly necessary.
However, a study of the hydrolysis of trimellitic anhydride acid chloride, has been performed in the context of the requirements for substances that may come into contact with food via packaging material. This study examined the behaviour of trimellitic anhydride acid chloride in unbuffered distilled water as a simple food simulant. Trimellitic anhydride acid chloride was found to hydrolyse completely at 40 °C in less than ½ hour to trimellitic acid and hydrogen chloride gas. Hydrolysis of the monomer was virtually instantaneous.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- This study addressed the issue of hydrolysis from the perspective of requirements for substances that may come into contact with food via packaging material and employed distilled water as a simple food simulant. The study was performed according to an appropriate guideline, though not to GLP.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Scientific Committee for Food CS/PM/1025 (August 1991)
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- trimellitic anhydride acid chloride
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Estimation method (if used):
- Not relevant
- Duration:
- 24 h
- Temp.:
- 40 °C
- Initial conc. measured:
- > 5.34 - < 5.61 µg/L
- Transformation products:
- yes
- No.:
- #1
- Key result
- Temp.:
- 40 °C
- DT50:
- < 30 min
- Remarks on result:
- other: Trimellitic anhydride chloride was hydrolysed completely within 30 minutes to trimellitic acid and HCl. The hydrolysis was so fast that it was considered to be virtually instantaneous.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Trimellitic anhydride acid chloride was found to hydrolyse completely in water food simulant at 40 °C in less than ½ hour to trimellitic acid and hydrogen chloride gas. The hydrolysis of the monomer is so rapid that it is virtually instantaneous. Similarly rapid hydrolysis is anticipated for trimellitic anhydride and trimellitic anhydride may therefore be expected to undergo almost instantaneous conversion to trimellitic acid on contact with aqueous matrices in the environment and in vivo in exposed humans and other organisms.
- Executive summary:
Trimellitic anhydride acid chloride (TMAC) was found to hydrolyse completely in water food simulant at 40 °C in less than ½ hour into trimellitic acid (TMLA) and hydrogen chloride gas. The rate of hydrolysis of the monomer is so rapid that it is virtually instantaneous.
Table 2: Hydrolysis of the monomer in water food simulant at 40°C
Time Period (Hours) |
Initial Concentration of monomer_µg/mL |
Concentration of trimellitic acid produced_µg/mL |
Percentage hydrolysis % w/w |
0 |
5.61 |
4.99 |
96 |
0 |
5.34 |
4.72 |
96 |
0 |
5.34 |
4.84 |
99 |
½ |
5.61 |
4.98 |
97 |
1 |
5.61 |
5.05 |
97 |
3 |
5.34 |
4.60 |
94 |
4 |
5.34 |
4.80 |
98 |
24 |
5.34 |
5.01 |
102 |
24 |
5.34 |
4.84 |
99 |
24 |
5.34 |
4.88 |
99 |
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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