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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal.
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Incidence of metal sensitivity in patients with total joint replacements.
Author:
M W ELVES, J N WILSON, J T SCALES, H B S KEMP
Year:
1975
Bibliographic source:
British medical journal 15 November 1975

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To observed the effect of ammonium molybdate which was used in patch test to 50 patient using Al-test strips.
GLP compliance:
not specified
Type of study:
patch test

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium molybdate(VI)
EC Number:
236-031-3
EC Name:
Ammonium molybdate(VI)
Cas Number:
13106-76-8
Molecular formula:
H4N.1/2MoO4
IUPAC Name:
ammonium molybdate(VI)
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid

In vivo test system

Test animals

Species:
other: Human
Strain:
other: not applicable
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, open
Vehicle:
not specified
Concentration / amount:
1%
Day(s)/duration:
3 days
No. of animals per dose:
50 patient
Details on study design:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Exposure period: 3 days
- Test groups: 50 patient
- Site: on the back and held in place with hypoallergic tape
- Frequency of applications: 1
- Duration: 3 days
- Concentrations: 1%
Challenge controls:
No data available
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: induction
Group:
test chemical
Dose level:
1% of ammonium molybdate
Total no. in group:
50
Clinical observations:
No reaction was observed
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

score used for observation

·         + erythema

·         ++ vesicular rash confined to area of patch

-      +++- extensive eczematous reaction beyond area of patch

Applicant's summary and conclusion

Interpretation of results:
other: Not sensitizing
Conclusions:
The ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.
Executive summary:

Patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day.

No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was considered to be non-sensitizing to human after exposure.