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EC number: 619-547-7 | CAS number: 211515-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- January 22,2007 to March 28,2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- - Commission Directive 92/69/EEC, Annex Part C, C. 1:"Acute Toxicity for Fish", Official Journal of the European Communities No. L 383 A, dated December 29, 1992 - OECD Guideline for Testing of Chemicals, Section 2, No. 203: "Fish, Acute Toxicity Test", adopted July 17, 1992 - OECD Series on Testing and Assessment, No. 23, "Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures", December 15,2000
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- and EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- No aged media was taken at the end of the study where all fish are dead to measure the concentration. No effect on the study is assumed as the fish were already dead after 30min no changes were assumed in the test media.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- CAT-Acid chloride
- IUPAC Name:
- CAT-Acid chloride
- Details on test material:
- Name: CAT-Acid Chloride
Certificate of Analysis Date: March 30, 2006
Aggregate State at Room Temperature: Liquid
Colour: Brown (according to BACON personnel)
Stability: Technical product, In water: the test item is considered to be stable under test
conditions
Expiry Date: July 03,2007
Storage: In original container, at 2-8 degree C, in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 13.27 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.8 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Analytical Method:
The test item was analysed using a TOC method.
Analytical Results:
At the start of the test just before introduction of the fish 39%
of the nominal test concentration was found (mean value of all
test concentrations). This calculation based on nominal test
concentrations not considering the fact that the test media were
filtrated to remove the non-dissolved part of the test item.
Therefore, this reduced findings are not surprising. In the aged
test media 58% of the nominal value was determined (mean
value of all test concentrations). Thus, during the test period the
fish were exposed to a mean of 48% of nominal (mean value of
all test concentrations). Therefore, all reported results are
related to the mean concentration of the test item.
TOC analysis can not differ between test item and degradation
products (both of them contribute to the signal, which is
evaluated). However, for the calculation of the recovery rate
this has not to be considered.
Validity Criteria of the Study:
Control: In the control no fish died until the end of the test.
Dissolved Oxygen Concentration: The dissolved oxygen concentration in the test media did not
fall below 60% of air saturation value during the test.
Biological Results:
Signs of Intoxication: In the control and at the test concentrations of 3.8 and 5.5 mg
test item/l mean measured concentration (MMC) all fish
survived until the end of the test. In contrast, in the test
concentration of 11 mg test item/l MMC two fish died after
72 hours and all fish died in the test concentration of 22 and
48 mg test item/l MMC after 24 and 2 hours of exposure,
respectively. The surviving fish showed several signsof
intoxication, e.g. strong ventilation, dark colouration, apathy,
fish lying on the side or back on the bottomofthe aquaria,
from the test concentrationof 5.5 mg test item/l MMC up to
the highest.
Measured Test Parameter:
pH-Values of the Test Water: pH 7.8 to 7.9
Dissolved Oxygen Concentrations: At least 8.9 mg/L or higher
Water Temperature: 14 to 15 degree C
Light Intensity: 410-580 lux
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the control and at the test concentrations of 3.8 and 5.5 mg test item/l mean measured concentration (MMC) all fish survived until the end of the test. In contrast, in the test concentration of 11 mg test item/l MMC two fish died after 72 hours and all fish died in the test concentration of 22 and 48 mg test item/l MMC after 24 and 2 hours of exposure, respectively. The surviving fish showed several signs of intoxication, e.g. strong ventilation, dark colouration, apathy, fish lying on the side or back on the bottom of the aquaria, from the test concentration of 5.5 mg test item/l MMC up to the highest.
- Executive summary:
Title:
Acute Toxicity of CAT-Acid Chloride to Rainbow Trout (Oncorhynchus mykiss) in a 96-hour Static Test
Guidelines/Recommendations:
- Commission Directive 92/69/EEC, Annex Part C,
C. 1:"Acute Toxicity for Fish", Official Journal of the
European Communities No. L 383 A, dated December 29,
1992
- OECD Guideline for Testing of Chemicals, Section 2, No.
203: "Fish, Acute Toxicity Test", adopted July 17, 1992
- OECD Series on Testing and Assessment, No. 23,
"Guidance Document on Aquatic Toxicity Testing of
Difficult Substances and Mixtures", December 15,2000
Purpose:
The purpose of this study was to evaluate the acute toxicity of
the test item CAT-Acid Chloride to fish. For this purpose,
juvenile Rainbow trout were exposed in a static test to aqueous
test media containing the test item at various concentrations
under defined conditions. The recorded effects were mortality
and symptoms of intoxication of the fish. A dose-response test
was performed in order to determine the relationship between
any effects seen and increasing test concentrations so that an
LC50 value could be determined.
The used method is recommended by the test guidelines, and
also Rainbow trout is one of the fish species recommended by
the international test guidelines of the OECD and EEC.
Since the test item is instable and insoluble in test water, it was
tested according to OECD No. 23 (Testing of Difficult
Substances). Therefore, the stock solution was stirred for 24
hours, in order to make allowance for the water insolubility of
the test item. The non-dissolved part of the test item was
afterwards removed by filtration. Due to the instability of the
test item, mainly the degradation products were tested.
The purpose of the analytical part of this study was to measure
the dissolved part of the test item and/or its degradation
products using measurement of Total Organic Carbon (TOC) as
sum parameter.
Water Hardness:
2.5 mmol/l (= 250.0 mg/l) as CaC03
Test Concentrations:
Filtrate of nominal 100 mg test item and 1:2, 1:4, 1:8, 1:16
dilutions of a filtrated stock solution of nominal 100 mg test
item (corresponding to mean measured concentration (MMC)
values of 48, 22, 11, 5.5, 3.8 mg test item) and a control.
Biological Results:
96-hour LC50: 13.27 mg test item/l MMC
95% Confidence Intervals: 11.74-15.01 mg test item/l MMC
96-hour LC0: 5.5 mg test item/l MMC
96-hour LC100: 22 mg test item/l MMC
96-hour NOEC: 3.8 mg test item/l MMC
96-hour LOEC: 5.5 mg test item/l MMC
Analytical Method:
The test item was analysed using a TOC method.
Analytical Results:
At the start of the test just before introduction of the fish 39 %
of the nominal test concentration was found (mean value of all
test concentrations). This calculation based on nominal test
concentrations not considering the fact that the test media were
filtrated to remove the non-dissolved part of the test item.
Therefore, this reduced findings are not surprising. In the aged
test media 58 % of the nominal value was determined (mean
value of all test concentrations). Thus, during the test period the
fish were exposed to a mean of 48% of nominal (mean value of
all test concentrations). Therefore, all reported results are
related to the mean concentration of the test item.
TOC analysis can not differ between test item and degradation
products (both of them contribute to the signal, which is
evaluated). However, for the calculation of the recovery rate
this has not to be considered.
Validity Criteria of the Study
Control: In the control no fish died until the end of the test.
Dissolved Oxygen Concentration: The dissolved oxygen concentration in the test media did not
fall below 60% of air saturation value during the test.
Biological Results
Signs of Intoxication: In the control and at the test concentrations of 3.8 and 5.5 mg
test item/l mean measured concentration (MMC) all fish
survived until the end of the test. In contrast, in the test
concentration of 11 mg test item/l MMC two fish died after
72 hours and all fish died in the test concentration of 22 and
48 mg test item/l MMC after 24 and 2 hours of exposure,
respectively. The surviving fish showed several signs of
intoxication, e.g. strong ventilation, dark colouration, apathy,
fish lying on the side or back on the bottom of the aquaria,
from the test concentration of 5.5 mg test item/l MMC up to
the highest.
Measured Test Parameter
pH-Values of the Test Water: pH 7.8 to 7.9
Dissolved Oxygen Concentrations: At least 8.9 mg/L or higher
Water Temperature: 14 to 15 degree C
Light Intensity: 410 - 580 lux
Conclusion:
In the control and at the test concentrations of 3.8 and 5.5 mg test item/l mean
measured concentration (MMC) all fish survived until the end of the test. In contrast, in the test concentration of 11 mg test item/l MMC two fish died after 72 hours and all fish died in the test concentration of 22 and 48 mg test item/l MMC after 24 and 2 hours of exposure, respectively. The surviving fish showed several signs of intoxication, e.g. strong ventilation, dark colouration, apathy, fish lying on the side or back on the bottom of the aquaria, from the test concentration of 5.5 mg test item/l MMC up to the highest.
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