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EC number: 285-083-3 | CAS number: 85029-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 for acute oral toxicity was determined to be > 5000 mg/kg bw
The LD50 for acute dermal toxicity was determined to be > 2500 mg/kg bw
The LC50 (8h) for acute inhalation toxicity was determined to be > 2.33 mg/L air.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Sept. 1973 to 03 Sept. 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to BASF-internal standard: 5 Sprague-Dawley rats (per sex and per dose) were exposed to the test substance via oral gavage at a dose of 5000 mg/kg bw. After an observation period of 7 days animals were necropsied and examined for clinical signs.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Neozapongelb R (TDA) Chromium-1.2-complex
performed under old CAS 73297-13-9
new CAS 85029-58-9, same structure - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 176 g; females 166 g
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Aqueous test substance preparation with CMC
Form of administration: suspension
Test concentration used: 16% (w/v)
Due to technical reasons, a higher test substance concentration (more than 16%) could not be administered. - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Feces brown coloured.
- Gross pathology:
- Nothing abnormal detected.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Sept. 1973 to 03 Sept. 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- According to BASF-internal standard: 6 rats (per sex per dose) were exposed via dust inhalation for 8 h. LC50 was determined after 8 h of exposure.
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Neozapongelb R (TDA) Chromium-1.2-complex
performed under old CAS 73297-13-9
new CAS 85029-58-9, same structure - Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: 201 g
- Route of administration:
- inhalation: dust
- Duration of exposure:
- 8 h
- Concentrations:
- Mean concentration: 2.33 mg/L
- No. of animals per sex per dose:
- 6 animals per sex per dose
3 animals per sex per control - Control animals:
- other: air control
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.33 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- None.
- Clinical signs:
- other: None.
- Body weight:
- Nothing abnormal detected.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Oct. 1973 to 03 Sept. 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- According to D.N. Noakes and D.M. Sanderson: A Method for Determing the Dermal Toxicity of Pesticides. Brit. J. Ind. Med. 26, 59, 1969
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Neozapongelb R (TDA) Chromium-1.2-complex
old CAS 73297-13-9
new CAS 85029-58-9, same structure - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 135 g, females 121 g
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- A 50% test substance concentration was used
Application area: 50 cm2 (average) - Duration of exposure:
- 24 h
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and local skin findings - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: During and after application as well as during the 14-day observation period the animals were vivacious.
- Gross pathology:
- Nothing abnormal detected
- Other findings:
- Local findings:
- After 24 hours all animals showed substance residues (light brown), reddening not visible
- After 8 days: no local effects observed in all animals, yellowish substance residues - Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 500 mg/kg bw
Additional information
Acute oral toxicity:
In an acute oral toxicity study, Sprague-Dawley rats (5 per sex per
group) were given a single dose of the test item in carboxymethyl
cellulose (CMR) at a dose of 5000 mg/kg bw (BASF 1974). Due to technical
reasons, a higher test substance concentration (more than 16%) could not
be applied. No mortality was observed within 7 days and the LD50 was
determined to be > 5000 mg/kg bw.
Acute inhalation toxicity:
In an acute inhalation toxicity study, rats (6 per sex per group)
were exposed by inhalation route to the test item at a mean
concentration of 2.33 mg/L for 8 hours. No deaths and no abnormalities
to the animals were observed after the exposure period. The LC50 (8h)
was determined to be > 2.33 mg/L.
Acute dermal toxicity:
In an acute dermal toxicity study, groups of Sprague-Dawley rats (5
animals per sex per group) were dermally exposed to the test substance
as a 50% aqueous test substance preparation by single dose of 2500 mg/kg
for 24 hours on clipped areas (about 50 cm²) of the back. Animals were
observed for 14 days. After 24 hours all animals showed tan substance
residues however reddening was not visible. After 8 days, yellowish
substance residues were visible however no effects were observed on any
of the animals. No mortality occurred within 14 days and the LD50 was
determined to be > 2500 mg/kg.
Justification for classification or non-classification
Based on the available information classification for acute oral toxicity and acute dermal toxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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