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EC number: 279-506-0 | CAS number: 80584-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-11-25 to 1982-12-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP but guideline study. The percent biodegradability was determined based on DOC measurements of flask 1 (flask 2 cracked during test).
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- yes
- Remarks:
- Measurements of DOC removal were not performed in duplicate. One test flask cracked during the test.
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- - Source of inoculum/activated sludge: Mixture of polyvalent bacteria
a) Secondary effluent from the sewage treatment plant of Rheinfelden, Switzerland.
b) In the river Rhine (Basle city, Switzerland)
c) From a suspension of garden soil from Vouvry, Switzerland - Duration of test (contact time):
- ca. 21 d
- Initial conc.:
- ca. 19.3 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to specifications of the OECD method No. 301 E
- Test temperature: 23±2 °C
- pH: no data
- pH adjusted: no data
- Continuous darkness: no, indirect daylight
TEST SYSTEM
- Culturing apparatus: 2000 mL erlenmeyer flasks
- Number of culture flasks: 2
- DOC measurement: weekly
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Positive control: Yes - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 76
- Sampling time:
- 21 d
- Details on results:
- Biodegradation measured as mg DOC/L and corrected by the blank control was calculated as 76 % in 21 days.
- Results with reference substance:
- Biodegradation corrected by the blank control and measured as DOC (mg/L) was 90 % in 7 days.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-11-23 to 1983-12-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study. Deviations from the updated OECD-guideline (adopted 1992): Filter was 0.45 instead of 0.20 micrometer.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- yes
- Remarks:
- Non GLP study. Deviations from the updated OECD-guideline (adopted 1992): Filter was 0.45 instead of 0.20 micrometer.
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- - Source of inoculum/activated sludge:
Mixture of polyvalent bacteria collected on 23/11/1983
a) Secondary effluent from the sewage treatment plant of CH~4310 Rheinfelden
b) In the river Rhine" (Basle-city)
c) From a suspension of garden soil from CH-1896 Vouvry - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: in accordance to the guideline
- Test temperature: 23 +/- 2 °C
- Continuous darkness: indirect daylight
TEST SYSTEM
- Culturing apparatus: 2000ml erlenmeyer flasks
- Number of culture flasks/concentration: duplicates
CONTROL AND BLANK SYSTEM
- Inoculum blank: one blank control - Reference substance:
- aniline
- Parameter:
- % degradation (DOC removal)
- Value:
- 68
- Sampling time:
- 28 d
- Details on results:
- Biodegradation measured as mg DOC/L and corrected by the blank control was calculated as 68 % in 28 days.
- Results with reference substance:
- Biodegradation corrected by the blank control and measured as DOC (mg/L) is 86 % in 14 days.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, only pre-test
- Qualifier:
- according to guideline
- Guideline:
- other: MITI guideline
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: standard sludge/water
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 30 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- two experimental set-ups were chosen:
A 100mg/L test material and 30mg/L active sludge
B 30mg/L test material and 100mg/L active sludge - Test performance:
- After pretreatlng cultured solution, HPLC analysis was carried out for organic solvent layer.
- Parameter:
- % degradation (TOC removal)
- Value:
- 64 - 73
- Sampling time:
- 28 d
- Remarks on result:
- other: 100 mg/L test mat
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 91 - 100
- Sampling time:
- 28 d
- Remarks on result:
- other: 100 mg/L test mat
- Parameter:
- % degradation (TOC removal)
- Value:
- 67
- Sampling time:
- 28 d
- Remarks on result:
- other: 30mg/L test mat.
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 100
- Sampling time:
- 28 d
- Remarks on result:
- other: 30 mg/L test mat
- Details on results:
- The test substance completely biodegrades within 28 days and generates multi-component-residue via degradation-intermediate.
Identification of the residues was not possible however, melamine formation could be excluded. - Endpoint:
- biodegradation in water: screening tests
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 306 Biodegradability in seawater
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: seawater
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): expected non-polluted location (90 m depth in the Trondheimsfjord, Norway)
- Storage conditions: stored in the dark in 10-l tanks at 20 ± 2 °C for degradation of inherent organic materials (aging).
- Storage length: 2 to 5 days
- Preparation of inoculum for exposure: aerated for 20 min, seawater fortified with nutrient solution enhancing bacterial growth
- Water filtered: yes
- Type and size of filter used, if any: 50 µm - Duration of test (contact time):
- 28 d
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Additional substrate: no
- Solubilising agent (type and concentration if used): not applicable
- Test temperature: 20±2 °C
- pH: no data
- pH adjusted: no data
- CEC (meq/100 g): no data
- Aeration of dilution water: no data
- Suspended solids concentration: no data
- Continuous darkness: yes
- Other: test substance diluted in "normal" seawater, which hda been aged for 3 to 5 days, essential nutrients for the bacteria added to the seawater
TEST SYSTEM
- Culturing apparatus: bottles with stoppers (no air space)
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: seawtaer aerated for 20 min prior to exposure
- Measuring equipment: "dissolved oxygen meter" (YSI Instruments, YSI Inc., Yellow Springs, OH, USA)
- Test performed in closed vessels due to significant volatility of test substance: not specified
- Test performed in open system: no
SAMPLING
- Sampling frequency: after 0, 5, 15 and 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: no
- Toxicity control: no
- Other: reference (aniline) - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 19.6
- Sampling time:
- 28 d
- Interpretation of results:
- other: The substance is poorly degradabale in seawater.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed according to a precursor of the OECD Modified Screening Test
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Version / remarks:
- precursor of OECD TG 301 E
- Principles of method if other than guideline:
- Modified OECD Screening Test performed according to:
OECD (1976). Proposed Method for the Determination of the Biodegradability of Surfactants Used in Synthetic Detergents. Paris.
Umweltbundesamt (1978). OECD Chemicals Testing Programme.Expert Group C "Persistence" (Degradation/Accumulation) Draft Working Papers, March 31, 1978 - GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: wwtp effluent (non-adapted)
- Duration of test (contact time):
- 19 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: medium with a trace metal solution and an essential vitamin solution; ammonium concentration tripled compared to OECD procedure for an optimal C:N:P ratio
- Additional substrate: no
- Solubilising agent (type and concentration if used): no
- Test temperature: ambient - Parameter:
- % degradation (DOC removal)
- Value:
- 96
- Sampling time:
- 19 d
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment. Key study because biodegradation under environmental conditions tested.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- CO2 evolution test
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Mixed liquor activated sludge (secondary effluent)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): West Bay County WWTP, Bay City, Michigan, treating primarily municipal sewage up to 4 mio gallons per day
- Duration of test (contact time):
- 6 d
- Initial conc.:
- > 600 - < 5 700 µg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: minimal salts basal medium according to Stainer et al. (1966; J Gen Microbiol 43: 159-271)
- Additional substrate: no
- Solubilising agent (type and concentration if used): no
- Test temperature: 25 °C
- pH:
- pH adjusted: yes/no
- CEC (meq/100 g):
- Aeration of dilution water:
- Suspended solids concentration:
- Continuous darkness: yes
- Other:
TEST SYSTEM
- Culturing apparatus: 500-mL polypropylene Erlenmeyer flasks, sealed with rubber stoppers and fitted with CO2 traps
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions:
- Method used to create anaerobic conditions:
- Measuring equipment:
- Test performed in closed vessels due to significant volatility of test substance:
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used: glass tubular CO2 traps (4 mL 1N KOH)
- Other: test material amended with 14C-TEA to yield 0.7 µCi/mL
SAMPLING
- Sampling frequency:
- Sampling method:
- Sterility check if applicable:
- Sample storage before analysis:
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank:
- Abiotic sterile control: yes, via addition of formaldehyde (final concentration: 2.8%)
- Toxicity control:
- Other: performed in duplicate
STATISTICAL METHODS: - Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 100
- Sampling time:
- 5 d
- Remarks on result:
- other: Primary biodegradation of 5.7 mg/l TEA in a test with 164 mg/l municipal activated sludge
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 100
- Sampling time:
- 1 d
- Remarks on result:
- other: Primary biodegradation of 0.6 mg/l TEA in a test with 164 mg/l municipal activated sludge
- Details on results:
- The rate constants in all test batches for degradation and mineralization are >0.359. According to GHS legislation, the substance is rapidly biodegradable. Therefore it can be assumed that the substance is also readily biodegradable.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: rapidly biodegradable according to GHS (readily biodegradability is therefore assumed)
Referenceopen allclose all
After 28 days 64 -73% removal of DOC was observed.
Days | mean DOC removal minus blanks |
7 | 32 |
14 | 30 |
21 | 66 |
27 | 68 |
28 | 68 |
Biodegradation (activated sludge):
Activated sludge (mg/L MLSS) |
Test item concentration (mg/L) |
Biodegradation rate constant (/d) |
Biodegradation half-life (d) |
CO2/ThCO2 (%) |
164 |
0.6 |
6.86 |
0.1 |
56+-10 |
164 |
5.7 |
1.36 |
0.51 |
54+-3 |
818 |
0.6 |
30 |
0.02 |
55+-1 |
818 |
5.7 |
6.7 |
0.01 |
52+-0 |
Mineralisation (activated sludge):
Activated sludge (mg/L MLSS) |
Test item concentration (mg/L) |
Mineralisation rate constant (/d) |
Mineralisation half-life (d) |
164 |
0.6 |
1.92 |
0.36 |
164 |
5.7 |
1.04 |
0.67 |
818 |
0.6 |
2.86 |
0.24 |
818 |
5.7 |
1.69 |
0.41 |
Description of key information
The compound consists of a triazine part and an amine part. Under environmental conditions it is present in its dissociated form. An OECD 301 E study is available for the compound itself. Additionally, separate assessments for biodegradation were conducted for the triazine and the amine part, respectively. In conclusion, neither the triazine nor the amine part of the compound can be regarded as persistent or even very persistent in the environment. The compound is readily biodegradable (by OECD criteria).
Key value for chemical safety assessment
Additional information
The compound consists of a triazine part and an amine part. Under environmental conditions it is present in its dissociated form. An OECD 301 E study is available for the compound itself. Additionally, separate assessments for biodegradation were conducted for the triazine and the amine part, respectively.
CAS 80584-92-5
The ready biodegradability of the test compound was assessed in a test following OECD guideline No. 301E (1981). The relative biodegradation values calculated from the measurements performed during the test period revealed 76 % biodegradation of the test compound.
In conclusion, the test compound is classified as readily biodegradable.
CAS 80584 -91 -4
The ready biodegradability of the triazine part was assessed in a modified OECD screening test in accordance to OECD guideline 301 E. The test item was exposed to the inoculum for 28 days. After exposure period a DOC removal of 68 % was detected. Therefore, the test item can be considered to be biodegradable but not readily biodegradable.
Furthermore, supporting data on biodegradation are available. The biodegradability of the test item was investigated under different sludge / test item ratios. TOC removal and removal of test item with specific analysis after 28 days exposure was investigated. The results indicate complete primary degradation after 28days and 68% biodegradability based on TOC removal after 28 days.
It can be concluded that the triazine part of the compound is not persistent or very persistent and at least inherently biodegradable not fulfilling specific criteria.
CAS 102 -71 -6
As key study regarding the biodegradation of the amine part a test performed by West et al. (1996) is identified. In a test with activated sludge biodegradation half-lifes between 0.01 and 0.51 days and mineralization half-lifes between 0.24 and 0.67 days were found, depending on the initial concentration of the test substance (164 and 818 mg/L) and the concentration of the activated sludge (0.6 and 5.7 mg/L MLSS).
These results indicate, that the compound is readily biodegradable. A ready test performed by Gerike (1978) according to a precursor of the Modified OECD Screeening Test (OECD TG 301 E) using non-adapted effluent from a waste water treatment plant as inoculum supports these results.
While the substance is readily biodegradable in freshwater systems, it is not readily biodegradable in seawater as concluded from an OECD 306 test published by Eide-Haugmo et al. (2009/2012) and Brakstad et al. (2012). The compound is not readily biodegradable in marine systems (19.6% ThBOD).
In conclusion, neither the triazine nor the amine part of the compound can be regarded as persistent or even very persistent in the environment.
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