Registration Dossier
Registration Dossier
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EC number: 217-192-9 | CAS number: 1770-80-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
- EC Number:
- 217-192-9
- EC Name:
- Dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
- Cas Number:
- 1770-80-5
- Molecular formula:
- C17H20Cl6O4
- IUPAC Name:
- dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
Constituent 1
Test animals / tissue source
- Species:
- cattle
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- neat, 750 µL
- Duration of treatment / exposure:
- 10 min
- Duration of post- treatment incubation (in vitro):
- 2h (illuminance measurement) and further 90 min (optical density measurement)
- Number of animals or in vitro replicates:
- 3 corneas per test item
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- mean
- Value:
- 2.03
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Remarks:
- none of the 3 corneas showed any opacity
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- When applied on bovine corneas, the test item had no eye irritancy potential. The mean irritation score was 2.03.
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