Registration Dossier
Registration Dossier
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EC number: 201-849-1 | CAS number: 88-66-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2-(dichloromethyl)benzene
- EC Number:
- 201-849-1
- EC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Cas Number:
- 88-66-4
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Details on test material:
- Purity > 99%
Impurities: 2-chlorobenzyl chloride and 2-chlorobenzotrichloride each < 0.2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Age at study initiation: no data
- Weight at study initiation: males: 181 g - 211 g (average 195 g); females: 174 g - 195 g (average 184 g)
- Fasting period before study: about 16 hours
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame oil
- Details on oral exposure:
- - Concentration in vehicle: 25%
MAXIMUM DOSE VOLUME APPLIED: 2.5, 3.15, 4.0, 4.24, 4.48, 5.6, 6.4, 10.0 ml/kg bw
- Doses:
- 630, 800, 1000, 1060, 1120, 1400, 1600, 2500 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology, histopathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 130 mg/kg bw
- 95% CL:
- > 954 - < 1 400
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 595 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- The LD50 value for acute oral toxicity is 1130 mg/kg bw in male Wistar rats and 595 mg/kg bw in female Wistar rats.
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