Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 617-219-8 | CAS number: 81334-34-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
In a 7-day algal growth inhibition test with Anabaena flos-aquae EC25 and EC50 values of 7.3 and 11.7 mg/L were determined, respectively. Anabaena flos-aquae was the most sensitive species tested.
Key value for chemical safety assessment
Additional information
Freshwater
Key study (American Cyanamid Company, 981 -86 -175, 1987)
A 7-day static freshwater test with cyanobacteria Anabaena flos-aquae was conducted equivalent to OECD guideline 201. Cyanobacteria were exposed to the test substance at nominal concentrations of 0, 5.6, 10, 18, 32, 56 and 100 mg/L. These nominal concentrations corresponds to the following mean measured concentrations: <0.02, 5.26, 9.6, 17.6, 30.2, 55.1 and 103 mg/L. Biomass was determined by cell counts on day 2, 3, 4 and 7. Percent inhibition or stimulation, relative to the control, was calculated for each concentration based upon the mean standing crop in cells/mL at seven days. Effects ranged from 4.8% stimulation to 99.4% inhibition. The 7-day EC25 was 7.3 mg/L (95% CI <0.0001 - 51.4 mg/L) and the 7-day EC50 was 11.7 mg/L (95% CI <0.0001 - 105.5 mg/L), based on mean measured concentrations.
Supporting study (American Cyanamid, Company, 981-86-172, 1987)
An additional 7-day freshwater test with freshwater algae Pseudokirchneriella subcapitata performed equivalent to OECD guideline 201 is available. The algae was exposed to nominal test substance concentrations of 0, 10, 18, 32, 56, and 100 mg/L. These nominal concentrations corresponds to the mean measured concentrations of <0.5, 9.4, 16.8, 30.8, 50.9 and 101.2 mg/L. Biomass was determined by cell counts on days 2, 3, 4 and 7. Percent inhibition or stimulation, relative to the control, was calculated for each test concentration based upon the standing crop in cells/mL at seven days. The 7-day EC25 and the 7-day EC50 was determined to be 48 and 71 mg/L respectively.
Supporting study (American Cyanamid, Company, 981-86-173, 1987)
An additional 7-day freshwater test with freshwater diatom Navicula pelliculosa performed equivalent to OECD guideline 201 is available. The freshwater diatom Navicula pelliculosa was exposed to nominal test substance concentrations of 0, 10, 18, 32, 56, and 100 mg/L. These nominal concentrations corresponds to the mean measured concentrations of <0.5, 8.2, 10.5, 23.5, 55.8 and 41.0 mg/L (the mean measured concentration for the highest nominal concentration, 100 mg/L, was actually lower than the mean measured concentration for the 56 mg/L nominal concentration). Biomass was determined by cell counts on days 2, 3, 4 and 7. Percent inhibition or stimulation, relative to the control, was calculated for each test concentration based upon the standing crop in cells/mL at seven days. All test concentrations were somewhat stimulatory to pelliculosa. Therefore, EC values could not be determined from the data. The 7-day EC25 and the 7-day EC50 would be greater than the highest mean measured test concentration of the test substance, 55.8 mg/L.
Marine water
Supporting study (American Cyanamid Company, 981-86-174, 1987)
In a 7-day study with the marine diatom Skeletonema costatum is available. Skeletonema costatum was exposed to the nominal test substance concentrations 0, 10, 18, 32, 56 and 100 mg/L, which corresponds to the mean measured concentrations of <1, 8.9, 15.9, 28.7, 47.4 and 90.5 mg/L. Biomass was determined by cell counts on day 2, 3, 4 and 7. Percent inhibition, relative to the control, was calculated for each concentration based upon the mean standing crop in cells/mL at seven days. Effects ranging from 0.7% to 54.0% inhibition were observed. The 7-day EC25 was 42.2 mg/L and the 7-day EC50 was 85.5 mg/L, based on mean measured test concentrations.
Conclusion:
Anabaena flos-aquae was the most sensitive species of the three tested algae species with an EC25 and EC50 of 7.3 and 11.7 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.